caa a22 4500 477106633 CHVBK 20180405111555.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01411725 doi (NATIONALLICENCE)springer-10.1007/BF01411725 CSF Neurotransmitter metabolites in comatose head injury patients during changes in their clinical state [Elektronische Daten] [M. Markianos, A. Seretis, A. Kotsou, M. Christopoulos] Summary: The main metabolites of noradrenaline, serotonin, and dopanine, methoxyhydroxyphenylglycol (MHPG), 5-hydroxyindoleacetic acid (5HIAA), and homovanillic acid (HVA), respectively, were assessed in CSF samples of patients in coma after severe head injury, the first days after the accident and again after an improvement (13 patients) or deterioration (7 patients) in their clinical state, evaluated by the score on the Glasgow Coma Scale. Improvement was accompanied by significant decreases in HVA and 5HIAA. In the patients who deteriorated, the levels of the three metabolites remained high. The results show that the increased turnover of CNS neurotransmitters in severe head injury normalizes during recovery. The use of noradrenaline, dopamine, and serotonin antagonists in brain injury experimental models may clarify the role of the increased biogenic amine turnover in the processes that lead to recovery. We propose relevant pharmacological intervention influencing neurotransmission in severe head injury. Springer-Verlag, 1996 Head injury nationallicence coma nationallicence amelioration nationallicence deterioration nationallicence CSF nationallicence MHPG nationallicence 5HIAA nationallicence HVA nationallicence Markianos M. Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Greece aut Seretis A. Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Greece aut Kotsou A. Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Greece aut Christopoulos M. Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Greece aut Acta Neurochirurgica Springer-Verlag 138/1(1996-01-01), 57-59 0001-6268 138:1<57 1996 138 701 https://doi.org/10.1007/BF01411725 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411725 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Markianos M. Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Greece aut NATIONALLICENCE 700 1- Seretis A. Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Greece aut NATIONALLICENCE 700 1- Kotsou A. Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Greece aut NATIONALLICENCE 700 1- Christopoulos M. Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Greece aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/1(1996-01-01), 57-59 0001-6268 138:1<57 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer