caa a22 4500 477106765 CHVBK 20180405111555.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF01411482 doi (NATIONALLICENCE)springer-10.1007/BF01411482 Delayed hyperglycemia and intracellular acidosis during focal cerebral ischemia in cats [Elektronische Daten] [R. Dempsey, M. Başkaya, D. Combs, D. Donaldson, A. Rao, M. Prasad] Summary: The effects of hyperglycemia on permanent focal brain ischemia is controversial; its effects on the size of the infarct are variable according to experimental conditions. In this study, nuclear magnetic resonance (NMR) spectroscopy was used to assess brain pH and high-energy phosphate metabolites after focal middle cerebral artery (MCA) ischemia in hyperglycemic and normoglycemic cats. Sixteen adult cats underwent (MCA) occlusion under general anesthesia and nuclear magnetic resonance31P spectroscopy to assess intracellular brain pH and energy metabolites throughout permanent ischemia. Animals were treated two hours after the onset of ischemia with either saline or glucose perfusions. Significant hyperglycemia (488 vs 105 mg/100 ml) was achieved in the experimental group. The response to hyperglycemia was dependent on the initial characteristics of the infants. A distinct pattern of phosphocreatine/inorganic phosphate recovery within 20 minutes of ischemia predicted a small infarct size. The addition of hyperglycemia did not affect acidosis, infarct size, or metabolite ratios in these animals. The lack of phosphocreatine/inorganic phosphate recovery within 20 minutes of ischemia was predictive of an eventual large infarct. In these animals, the delayed addition of hyperglycemia significantly lowered intracellular pH during the ischemie period (5.45 vs. 6.25, p = 0.25). These data support the theory that the response to hyperglycemia is very dependent on the initial metabolic state of the injured brain. This state can be predicted by early31P spectroscopy data, which may, in turn, prove to be a useful marker for recoverable ischemic deficit in the cerebral region of interest. Springer-Verlag, 1996 Brain acidosis nationallicence brain infarction nationallicence focal ischemia nationallicence NMR nationallicence Dempsey R. Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center and Veterans Administration Center, Lexington, Kentucky, USA aut Başkaya M. Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center and Veterans Administration Center, Lexington, Kentucky, USA aut Combs D. Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center and Veterans Administration Center, Lexington, Kentucky, USA aut Donaldson D. Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center and Veterans Administration Center, Lexington, Kentucky, USA aut Rao A. Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center and Veterans Administration Center, Lexington, Kentucky, USA aut Prasad M. Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center and Veterans Administration Center, Lexington, Kentucky, USA aut Acta Neurochirurgica Springer-Verlag 138/6(1996-06-01), 745-751 0001-6268 138:6<745 1996 138 701 https://doi.org/10.1007/BF01411482 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411482 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dempsey R. Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center and Veterans Administration Center, Lexington, Kentucky, USA aut NATIONALLICENCE 700 1- Başkaya M. Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center and Veterans Administration Center, Lexington, Kentucky, USA aut NATIONALLICENCE 700 1- Combs D. Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center and Veterans Administration Center, Lexington, Kentucky, USA aut NATIONALLICENCE 700 1- Donaldson D. Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center and Veterans Administration Center, Lexington, Kentucky, USA aut NATIONALLICENCE 700 1- Rao A. Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center and Veterans Administration Center, Lexington, Kentucky, USA aut NATIONALLICENCE 700 1- Prasad M. Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center and Veterans Administration Center, Lexington, Kentucky, USA aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/6(1996-06-01), 745-751 0001-6268 138:6<745 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer