caa a22 4500 47710682X CHVBK 20180405111556.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF01411481 doi (NATIONALLICENCE)springer-10.1007/BF01411481 Brain energy metabolism in the acute stage of experimental subarachnoid haemorrhage: Local changes in cerebral glucose utilization [Elektronische Daten] [D. d'Avella, R. Cicciarello, M. Zuccarello, F. Albiero, A. Romano, F. Angileri, F. Salpietro, F. Tomasello] Summary: An experimental model was used to investigate acute alterations of cerebral metabolic activity in rats subjected to subarachnoid haemorrhage (SAH). Haemorrhages were produced in anaesthetized animals by injecting 0.3 ml of autologous, arterial nonheparinized blood into the cisterna magna. Control rats received subarachnoid injections of mock-cerebrospinal fluid to study the effect of sudden raised intracranial pressure, or underwent sham operation. Three hours after SAH rats were given an intravenous injection of [14C]-2-deoxyglucose. Experiments were terminated by decapitation, and the brains were removed and frozen. Regional brain metabolic activity was studied by quantitative autoradiography. In comparison with sham-operated controls, cerebral metabolic activity was diffusely decreased after SAH. Statistically significant decreases in metabolic rate were observed in 23 of 27 brain regions studied. Subarachnoid injections of mock-cerebrospinal fluid also produced depression of cerebral metabolic activity, but quantitatively these changes were not as pronounced and diffuse as in SAH rats. The present study shows that a widespread depression of brain metabolism occurs in the acute stage after experimental SAH and is probably secondary to the Subarachnoid presence of blood itself and/or blood products. Springer-Verlag, 1996 Autoradiography nationallicence cerebral metabolism nationallicence rat nationallicence subarachnoid haemorrhage nationallicence d'Avella D. Neurosurgical Clinic, University of Messina Medical School, Messina, Italy aut Cicciarello R. Institute of Oncology, University of Messina Medical School, Messina, Italy aut Zuccarello M. Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA aut Albiero F. Institute of Oncology, University of Messina Medical School, Messina, Italy aut Romano A. Neurosurgical Clinic, University of Messina Medical School, Messina, Italy aut Angileri F. Neurosurgical Clinic, University of Messina Medical School, Messina, Italy aut Salpietro F. Neurosurgical Clinic, University of Messina Medical School, Messina, Italy aut Tomasello F. Neurosurgical Clinic, University of Messina Medical School, Messina, Italy aut Acta Neurochirurgica Springer-Verlag 138/6(1996-06-01), 737-744 0001-6268 138:6<737 1996 138 701 https://doi.org/10.1007/BF01411481 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411481 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- d'Avella D. Neurosurgical Clinic, University of Messina Medical School, Messina, Italy aut NATIONALLICENCE 700 1- Cicciarello R. Institute of Oncology, University of Messina Medical School, Messina, Italy aut NATIONALLICENCE 700 1- Zuccarello M. Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA aut NATIONALLICENCE 700 1- Albiero F. Institute of Oncology, University of Messina Medical School, Messina, Italy aut NATIONALLICENCE 700 1- Romano A. Neurosurgical Clinic, University of Messina Medical School, Messina, Italy aut NATIONALLICENCE 700 1- Angileri F. Neurosurgical Clinic, University of Messina Medical School, Messina, Italy aut NATIONALLICENCE 700 1- Salpietro F. Neurosurgical Clinic, University of Messina Medical School, Messina, Italy aut NATIONALLICENCE 700 1- Tomasello F. Neurosurgical Clinic, University of Messina Medical School, Messina, Italy aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/6(1996-06-01), 737-744 0001-6268 138:6<737 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer