caa a22 4500 477106870 CHVBK 20180405111556.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF01412315 doi (NATIONALLICENCE)springer-10.1007/BF01412315 Accuracy of an experimental stereotactic system for MRI-based Gamma Knife irradiation in the rat [Elektronische Daten] [T. Kamiryo, S. Berr, H. Berk, K. Lee, N. Kassell, L. Steiner] Summary: Stereotactic devices for experimental Gamma Knife irradiation and magnetic resonance imaging (MRI) have recently been developed for experimental studies using rats [6, 7]. The present study examined the accuracy of these devices using the following two approaches. In the first approach, Gamma Knife irradiation was performed using the stereotactic device with targets based on a standard stereotactic atlas. Gadolinium-enhanced T1-weighted magnetic resonance imaging was performed using the MRI stereotactic device. Animals were then sacrificed after Evans blue injection, and the rat brain was sliced using an attachment to the stereotactic device. The center coordinates of the gadolinium-enhanced area from the MRI and Evans blue-stained area from the tissue sections were obtained using a computer-assisted image analysis system. These coordinates were compared with the target coordinates planned from the stereotactic atlas. In the second approach, a thermoluminescence dosimeter was implanted in the rat brain. Stereotactic MRI was performed using the stereotactic MRI device, and the coordinates of the implant were obtained. Gamma Knife irradiation was then performed at this target using the stereotactic device. The absorbed dose was measured and compared with the planning dose. These experiments demonstrated a spatial error of 0.6 mm (standard error ± 0.07) between Gamma Knife irradiation based on a comparison of the atlas coordinates and the lesion, and a spatial error of 1.0 mm (standard error ± 0.13) based on a comparison of the stereotactic MR images and the lesion. Gamma Knife irradiation based on MR images using the stereotactic device demonstrated a maximum error of 10% in absorbed dose at the target center. Together, the stereotactic devices for Gamma Knife irradiation and magnetic resonance imaging provide useful tools for Gamma Knife research in an animal model. Springer-Verlag, 1996 Gamma Knife nationallicence MRI nationallicence Stereotactic atlas nationallicence rat nationallicence stereotactic device nationallicence Kamiryo T. Department of Neurological Surgery, Virginia Neurological Institute, USA aut Berr S. Department of Radiology, University of Virginia, Health Sciences Center, Charlottesville, VA, USA aut Berk H. Department of Radiology, University of Virginia, Health Sciences Center, Charlottesville, VA, USA aut Lee K. Department of Neurological Surgery, Virginia Neurological Institute, USA aut Kassell N. Department of Neurological Surgery, Virginia Neurological Institute, USA aut Steiner L. Department of Neurological Surgery, Virginia Neurological Institute, USA aut Acta Neurochirurgica Springer-Verlag 138/9(1996-09-01), 1103-1108 0001-6268 138:9<1103 1996 138 701 https://doi.org/10.1007/BF01412315 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01412315 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kamiryo T. Department of Neurological Surgery, Virginia Neurological Institute, USA aut NATIONALLICENCE 700 1- Berr S. Department of Radiology, University of Virginia, Health Sciences Center, Charlottesville, VA, USA aut NATIONALLICENCE 700 1- Berk H. Department of Radiology, University of Virginia, Health Sciences Center, Charlottesville, VA, USA aut NATIONALLICENCE 700 1- Lee K. Department of Neurological Surgery, Virginia Neurological Institute, USA aut NATIONALLICENCE 700 1- Kassell N. Department of Neurological Surgery, Virginia Neurological Institute, USA aut NATIONALLICENCE 700 1- Steiner L. Department of Neurological Surgery, Virginia Neurological Institute, USA aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/9(1996-09-01), 1103-1108 0001-6268 138:9<1103 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer