caa a22 4500 477106889 CHVBK 20180405111556.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF01412305 doi (NATIONALLICENCE)springer-10.1007/BF01412305 Cell kinetic analysis in recurrent neuro-epithelial tumours [Elektronische Daten] [É. Gömöri, I. Mészáros, G. Méhes, T. Dóczi, L. Pajor] Summary: The biological behaviour of brain tumours is variable. In the majority of cases, recurrence of the tumour is the decisive factor determining the prognosis and individual survival of patients suffering from a neuro-epithelial neoplasm. The time course of recurrences varies significantly according to differences in tumour cell proliferation. In this study, predictive factors concerning the expected prognosis following the resection of neuro-epithelial tumours were investigated with the aim of improving the histological diagnosis. A retrospective analysis of 22 recurrent neuro-epithelial tumours (recurrent tumour group) and 12 neuro-epithelial tumours with a minimum survival rate of 5 years following radical excision (cured tumour group) was performed by means of flow cytometry and immunohistochemistry using the MIB 1 antibody. Histological samples of the subgroups of the recurrent tumour group, i. e., the primary tumours and their recurrences were compared with each other, and the subgroups were compared with the cured tumour group. A multivariate analysis of the data was performed with the BMPD Hotteling T square test. A statistically significant difference was found between the recurrent tumour group (primary tumours + recurrences) and the cured group from every investigated aspect. On the other hand, no difference could be found between the subgroups primary tumours and their recurrences. All tumours in the recurrent group had an accelerated, active cell cycle, which was expressed in a high proliferation activity. The following conclusion was drawn:an increased risk of recurrence is to be expected in neuro-epithelial tumours characterized by: an S-phase fraction higher than 6-9%, an MIB 1-labelled cell number higher than 2-3/high-power fields, and a number of mitoses higher than 1/10 high-power fields. Springer-Verlag, 1996 Cell proliferation nationallicence flow cytometry nationallicence neuro-epithelial tumours nationallicence recurrence nationallicence Gömöri É. Department of Pathology, University Medical School, Pécs, Hungary aut Mészáros I. Department of Neurosurgery, University Medical School, Pécs, Hungary aut Méhes G. Department of Pathology, University Medical School, Pécs, Hungary aut Dóczi T. Department of Neurosurgery, University Medical School, Pécs, Hungary aut Pajor L. Department of Pathology, University Medical School, Pécs, Hungary aut Acta Neurochirurgica Springer-Verlag 138/9(1996-09-01), 1036-1041 0001-6268 138:9<1036 1996 138 701 https://doi.org/10.1007/BF01412305 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01412305 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gömöri É. Department of Pathology, University Medical School, Pécs, Hungary aut NATIONALLICENCE 700 1- Mészáros I. Department of Neurosurgery, University Medical School, Pécs, Hungary aut NATIONALLICENCE 700 1- Méhes G. Department of Pathology, University Medical School, Pécs, Hungary aut NATIONALLICENCE 700 1- Dóczi T. Department of Neurosurgery, University Medical School, Pécs, Hungary aut NATIONALLICENCE 700 1- Pajor L. Department of Pathology, University Medical School, Pécs, Hungary aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/9(1996-09-01), 1036-1041 0001-6268 138:9<1036 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer