caa a22 4500 47710696X CHVBK 20180405111556.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF01412316 doi (NATIONALLICENCE)springer-10.1007/BF01412316 Effect of ketanserin on 5-hydroxytryptamine-induced constriction in isolated, perfused canine basilar arteries exposed to blood [Elektronische Daten] [T. Tsuji, D. Cook] Summary: The blocking effect of ketanserin, a 5-hydroxytryptamine (5-HT)2 receptor antagonist, was examined on responses to intraluminal 5-HT or potassium chloride (KC1) in isolated and perfused canine basilar arteries before and after extraluminal whole blood by means of the stainless-steel cannula inserting method. Four hours after the application of blood, the constriction to 5-HT was significantly enhanced, while that to KC1 was significantly attenuated. The absolute value in the decrease of perfusion pressure for the 5-HT-induced constriction sensitive to ketanserin was much greater after the blood application than that before the application. It is suggested that the augmentation of cerebrovascular responses to 5-HT in the early stage immediately after subarachnoid haemorrhage (SAH) might be mediated by 5-HT2 receptors at least in part. This early constrictor mechanism may be implicated in the aetiology of the following late stage of cerebral vasospasm after SAH. Springer-Verlag, 1996 Cerebral vasospasm nationallicence 5-hydroxytryptamine nationallicence ketanserin nationallicence subarachnoid haemorrhage nationallicence Tsuji T. Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan aut Cook D. Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada aut Acta Neurochirurgica Springer-Verlag 138/9(1996-09-01), 1109-1117 0001-6268 138:9<1109 1996 138 701 https://doi.org/10.1007/BF01412316 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01412316 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tsuji T. Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan aut NATIONALLICENCE 700 1- Cook D. Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/9(1996-09-01), 1109-1117 0001-6268 138:9<1109 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer