caa a22 4500 47710701X CHVBK 20180405111556.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF01412318 doi (NATIONALLICENCE)springer-10.1007/BF01412318 Cytochrome oxidase activity during acute focal ischaemia in rat brain [Elektronische Daten] A pathophysiology of acute focal ischaemia: Part 2 [N. Inoue, S. Goto, K. Korematsu, T. Oyama, K. Yamada, S. Nagahiro, Y. Ushio] Summary: An enzyme-histochemical technique was used to examine the changes in cytochrome oxidase activity during acute focal ischaemia in the rat. In the somatosensory cortex, the enzyme activity began to increase significantly (p < 0.01) 1 hour after middle cerebral artery occlusion (MCAO) and continued to increase up to 3 hours, during which ischaemic cell damage was not detected. In the striatum, the enzyme activity increased significantly (p < 0.01) 1 hour after MCAO in the absence of morphological evidence of ischaemic cell damage; a peak activity was reached at 2 hours, and began to decline 3 hours after MCAO when moderate ischaemic change was detected. In both cortical and subcortical areas, the enzyme activity tended to decrease from 4 hours after MCAO, and was reduced to a level similar to or below that of the non-ischaemic hemisphere 5 hours after MCAO, when severe ischaemic damage was demonstrated. The relation of this transient increase of cytochrome oxidase activity in the early stage of acute ischaemia and the hypermetabolism of neuronal cells during ischaemic insult was discussed. Springer-Verlag, 1996 Cerebral ischaemia nationallicence ischaemic brain damage nationallicence cytochrome oxidase nationallicence middle cerebral artery occlusion nationallicence Inoue N. Laboratory for Cerebrovascular Disorders and Neuroscience, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan aut Goto S. Laboratory for Cerebrovascular Disorders and Neuroscience, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan aut Korematsu K. Laboratory for Cerebrovascular Disorders and Neuroscience, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan aut Oyama T. Laboratory for Cerebrovascular Disorders and Neuroscience, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan aut Yamada K. Laboratory for Cerebrovascular Disorders and Neuroscience, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan aut Nagahiro S. Laboratory for Cerebrovascular Disorders and Neuroscience, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan aut Ushio Y. Laboratory for Cerebrovascular Disorders and Neuroscience, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan aut Acta Neurochirurgica Springer-Verlag 138/9(1996-09-01), 1126-1131 0001-6268 138:9<1126 1996 138 701 https://doi.org/10.1007/BF01412318 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01412318 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Inoue N. Laboratory for Cerebrovascular Disorders and Neuroscience, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan aut NATIONALLICENCE 700 1- Goto S. Laboratory for Cerebrovascular Disorders and Neuroscience, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan aut NATIONALLICENCE 700 1- Korematsu K. Laboratory for Cerebrovascular Disorders and Neuroscience, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan aut NATIONALLICENCE 700 1- Oyama T. Laboratory for Cerebrovascular Disorders and Neuroscience, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan aut NATIONALLICENCE 700 1- Yamada K. Laboratory for Cerebrovascular Disorders and Neuroscience, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan aut NATIONALLICENCE 700 1- Nagahiro S. Laboratory for Cerebrovascular Disorders and Neuroscience, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan aut NATIONALLICENCE 700 1- Ushio Y. Laboratory for Cerebrovascular Disorders and Neuroscience, Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/9(1996-09-01), 1126-1131 0001-6268 138:9<1126 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer