caa a22 4500 477107133 CHVBK 20180405111557.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF01411267 doi (NATIONALLICENCE)springer-10.1007/BF01411267 The role of angiogenic factor bFGF in the development of dural AVFs [Elektronische Daten] [T. Terada, M. Tsuura, N. Komai, R. Higashida, V. Halbach, C. Dowd, C. Wilson, G. Hieshima] Summary: Purpose: Dural arteriovenous fistulas (dAVFs) are known to be acquired disorders. Angiogenic stimulants, such as basic fibroblast growth factor (bFGF), may be involved in the evolution of this disorder. We examined the appearance and localization of bFGF, in human dAVF sinuses, versus a control using immunohistochemical techniques, to evaluate these qualitative differences. Patients and methods: Four human dural sinuses from dAVF patients, and one control dural sinus were removed at surgery or autopsy and used for this study. Immunohistochemistry for bFGF was performed in all five specimens to identify its appearance and localization. Immunohistochemistry for alpha smooth muscle actin, factor VIII related antigen, and macrophage (CD-68) were done in all tissues to identify the bFGF positive cell types. Results: In the control dural sinus, there was negative staining by bFGF immunohistochemistry. However, in all four sinuses of the dAVF patients, smooth muscle cells, endothelial cells, and meningeal cells were stained positively in various degrees by bFGF immunohistochemistry. Conclusion: bFGF may be significant in the development of dAVFs, judging from its strong immunoreactivity in the sinuses of dAVF patients. Springer-Verlag, 1996 Angiogenic factor bFGF nationallicence dural AVF nationallicence Terada T. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut Tsuura M. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut Komai N. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut Higashida R. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut Halbach V. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut Dowd C. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut Wilson C. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut Hieshima G. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut Acta Neurochirurgica Springer-Verlag 138/7(1996-07-01), 877-883 0001-6268 138:7<877 1996 138 701 https://doi.org/10.1007/BF01411267 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411267 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Terada T. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut NATIONALLICENCE 700 1- Tsuura M. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut NATIONALLICENCE 700 1- Komai N. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut NATIONALLICENCE 700 1- Higashida R. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut NATIONALLICENCE 700 1- Halbach V. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut NATIONALLICENCE 700 1- Dowd C. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut NATIONALLICENCE 700 1- Wilson C. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut NATIONALLICENCE 700 1- Hieshima G. Department of Neurological Surgery, Wakayama Medical College, Wakayama City, Japan aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/7(1996-07-01), 877-883 0001-6268 138:7<877 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer