caa a22 4500 477107265 CHVBK 20180405111557.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF01411118 doi (NATIONALLICENCE)springer-10.1007/BF01411118 Outcome of 31 intracranial haemangiopericytomas: Poor predictive value of cell proliferation indices [Elektronische Daten] [V. Vuorinen, P. Sallinen, H. Haapasalo, T. Visakorpi, M. Kallio, J. Jääskeläinen] Summary: Cell proliferation indices of 31 primary intracranial haemangiopericytomas (HPC) and their recurrences and metastases were correlated with the long-term recurrence, metastasis and survival rates. Paraffin-embedded specimens were used for K-67, PCNA and p53 immunostainings and for estimation of S-phase fraction (S-PF) in flow cytometry. The median Ki-67 and PCNA indices and S-PFs were 10.4, 3.2, and 4.0 for primary HPCs and 14.1, 14.1, and 5.5 for recurrences, respectively. High indices were associated with higher recurrence, metastasis and death rates, but not at the p ≤ 0.5 level. Consequently, these indices do not seem useful in planning of treatment and follow-up of meningeal HPCs. Meningeal HPCs, in contrast to meningiomas, recur almost always despite seemingly complete removal and often metastasize elsewhere in the body. This difference between two sharply demarcated tumours must reflect particularly adhesive and infiltrative properties of HPC cells and not just higher proliferation potential. Springer-Verlag, 1996 Haemangiopericytoma nationallicence intracranial nationallicence outcome nationallicence proliferation indices nationallicence p53 nationallicence Vuorinen V. Department of Neurosurgery, University of Helsinski, Finland aut Sallinen P. Department of Neurology, University of Helsinski, Finland aut Haapasalo H. Department of Pathology, University of Tampere, Finland aut Visakorpi T. Department of Clinical Chemistry, University of Tampere, Finland aut Kallio M. Department of Neurology, University of Helsinski, Finland aut Jääskeläinen J. Department of Neurosurgery, University of Helsinski, Finland aut Acta Neurochirurgica Springer-Verlag 138/12(1996-12-01), 1399-1408 0001-6268 138:12<1399 1996 138 701 https://doi.org/10.1007/BF01411118 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411118 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vuorinen V. Department of Neurosurgery, University of Helsinski, Finland aut NATIONALLICENCE 700 1- Sallinen P. Department of Neurology, University of Helsinski, Finland aut NATIONALLICENCE 700 1- Haapasalo H. Department of Pathology, University of Tampere, Finland aut NATIONALLICENCE 700 1- Visakorpi T. Department of Clinical Chemistry, University of Tampere, Finland aut NATIONALLICENCE 700 1- Kallio M. Department of Neurology, University of Helsinski, Finland aut NATIONALLICENCE 700 1- Jääskeläinen J. Department of Neurosurgery, University of Helsinski, Finland aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/12(1996-12-01), 1399-1408 0001-6268 138:12<1399 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer