caa a22 4500 477107397 CHVBK 20180405111557.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF01411123 doi (NATIONALLICENCE)springer-10.1007/BF01411123 Cellular targets of exogenous tumour necrosis factor-alpha (TNFα) in human gliomas [Elektronische Daten] [M. Maruno, T. Yoshimine, T. Isaka, A. Ghulam Muhammad, K. Nishioka, T. Hayakawa] Summary: To identify the cellular targets of TNFα in human gliomas, a total of 30 surgical specimens (12 glioblastomas, 4 anaplastic astrocytomas, 3 astrocytomas, 7 brains adjacent to tumour (BAT), 4 histologically normal-appearing brains) were examined by in vitro binding technique using biotinylated TNFa. The TNF-binding sites (TNF-BS) were recognized in the tumour cells in 8 of the 12 glioblastomas. 3 of the 4 anaplastic astrocytomas and in all the 3 astrocytomas. The TNF-BS were also recognized in the vascular endothelial cells in all these cases. The presence of TNF-BS in blood vessels ranged from 7.7 to 74.4% of the background vessels. This wide range of variation in the presence of TNF-BS within the tumour cells and tumour blood vessels may be relevant to the variable response of individual tumours to TNFα therapy. Since the tissue of normal brain, which lacks TNF-BS, might hardly be affected by this cytokine, administration of TNFa may be considered as an adjuvant therapy in selected groups of patients. Springer-Verlag, 1996 TNF-binding sites nationallicence gliomas nationallicence endothelial cells nationallicence Maruno M. Department of Neurosurgery, Osaka University Medical School, Osaka, Japan aut Yoshimine T. Department of Neurosurgery, Osaka University Medical School, Osaka, Japan aut Isaka T. Department of Neurosurgery, Osaka University Medical School, Osaka, Japan aut Ghulam Muhammad A. Department of Neurosurgery, Osaka University Medical School, Osaka, Japan aut Nishioka K. Department of Neurosurgery, Osaka University Medical School, Osaka, Japan aut Hayakawa T. Department of Neurosurgery, Osaka University Medical School, Osaka, Japan aut Acta Neurochirurgica Springer-Verlag 138/12(1996-12-01), 1437-1441 0001-6268 138:12<1437 1996 138 701 https://doi.org/10.1007/BF01411123 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411123 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maruno M. Department of Neurosurgery, Osaka University Medical School, Osaka, Japan aut NATIONALLICENCE 700 1- Yoshimine T. Department of Neurosurgery, Osaka University Medical School, Osaka, Japan aut NATIONALLICENCE 700 1- Isaka T. Department of Neurosurgery, Osaka University Medical School, Osaka, Japan aut NATIONALLICENCE 700 1- Ghulam Muhammad A. Department of Neurosurgery, Osaka University Medical School, Osaka, Japan aut NATIONALLICENCE 700 1- Nishioka K. Department of Neurosurgery, Osaka University Medical School, Osaka, Japan aut NATIONALLICENCE 700 1- Hayakawa T. Department of Neurosurgery, Osaka University Medical School, Osaka, Japan aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/12(1996-12-01), 1437-1441 0001-6268 138:12<1437 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer