caa a22 4500 477107567 CHVBK 20180405111558.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF01411744 doi (NATIONALLICENCE)springer-10.1007/BF01411744 Correlation between spinal cord blood flow and arterial diameter following acute spinal cord injury in rats [Elektronische Daten] [T. Ohashi, T. Morimoto, K. Kawata, T. Yamada, T. Sakaki] Summary: Simultaneous measurements of spinal cord blood flow and arterial diameter at areas adjacent to a site of spinal cord injury were carried out to determine changes in CO2 reactivity and autoregulation. The spinal cord injury was made at T10 level by the epidural clip compression method. A spinal window was drilled at an area either 7 mm caudal or 7 mm rostral to the injury site for the measurement of spinal cord blood flow and arterial diameter at the same time. Spinal cord blood flow was decreased at both spinal windows, especially at the rostral window. Arterial diameter was also decreased significantly at both sites. The ischaemic zone evaluated histologically tended to expand more diffusely in the rostral direction than in the caudal direction. In the pre-injury stage, both CO2 reactivity and autoregulation were present in the spinal cord. Following the clip injury, CO2 reactivity and autoregulation were both impaired in the areas 7 mm adjacent to the impact site. Correlation coefficients suggested that the rostral spinal cord tended to sustain more injury than the caudal spinal cord. The histologically proven spinal cord ischaemia following the injury may have resulted from the decreased arterial diameter and impaired CO2 reactivity and dysautoregulation of the spinal cord. Springer-Verlag, 1996 Spinal cord injury nationallicence spinal cord blood flow nationallicence arterial diameter nationallicence CO2 reactivity nationallicence autoregulation nationallicence Ohashi T. Department of Neurosurgery, Nara Medical University, Shijo-cho, Kashihara, Japan aut Morimoto T. Department of Neurosurgery, Nara Medical University, Shijo-cho, Kashihara, Japan aut Kawata K. Department of Neurosurgery, Nara Medical University, Shijo-cho, Kashihara, Japan aut Yamada T. Department of Neurosurgery, Nara Medical University, Shijo-cho, Kashihara, Japan aut Sakaki T. Department of Neurosurgery, Nara Medical University, Shijo-cho, Kashihara, Japan aut Acta Neurochirurgica Springer-Verlag 138/3(1996-03-01), 322-329 0001-6268 138:3<322 1996 138 701 https://doi.org/10.1007/BF01411744 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411744 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohashi T. Department of Neurosurgery, Nara Medical University, Shijo-cho, Kashihara, Japan aut NATIONALLICENCE 700 1- Morimoto T. Department of Neurosurgery, Nara Medical University, Shijo-cho, Kashihara, Japan aut NATIONALLICENCE 700 1- Kawata K. Department of Neurosurgery, Nara Medical University, Shijo-cho, Kashihara, Japan aut NATIONALLICENCE 700 1- Yamada T. Department of Neurosurgery, Nara Medical University, Shijo-cho, Kashihara, Japan aut NATIONALLICENCE 700 1- Sakaki T. Department of Neurosurgery, Nara Medical University, Shijo-cho, Kashihara, Japan aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/3(1996-03-01), 322-329 0001-6268 138:3<322 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer