caa a22 4500 477107672 CHVBK 20180405111559.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/BF01809748 doi (NATIONALLICENCE)springer-10.1007/BF01809748 Noninvasive differentiation of meningiomas from other brain tumours using combined111indium-octreotide/99mtechnetium-DTPA brain scintigraphy [Elektronische Daten] [A. Barth, A. Haldemann, J. Reubi, N. Godoy, H. Rösier, J. Kinser, R. Seiler] Summary: We have studied prospectively 47 patients with CNS tumours including 16 meningiomas and 33 other tumours using combined111In-octreotide and99mTc-DTPA brain scintigraphy.111In-octreotide scintigraphy was used to image somatostatin receptors (SSR) and99mTc-DTPA scintigraphy was used to assess the integrity of the blood-brain barrier (BBB). A total of 32 tumours (65%) were detected. All SSR positive tumours also had positive99mTc-DTPA scans and all SSR negative tumours were negative on99mTc-DTPA scans. Among the tumours located outside the BBB, all meningiomas and two out of six schwannomas were positive on combined SSR/99mTc-DTPA scintigraphy. Among the tumours located inside the BBB, seven out of nine gliomas grade I-III were negatitve, whereas all glioblastomas were positive. Other positive tumours included one malignant non-Hodgkin lymphoma and two cerebral metastases. SSR scintigraphy alone was non-specific in the diagnosis of meningiomas, as 16 non-meningiomatous tumours also had positive SSR scans probably due to a breakdown of the BBB (excluding the malignant lymphoma). Measuring the tumour-to-background ratio on SSR scans improved specificity, but sensitivity was decreased below 70% because some meningiomas were only slightly positive. Only the ratio of SSR scintigraphy to conventional99mTc-DTPA brain scintigraphy (SSR-to-BS index) allowed a reliable differentiation of meningiomas from other CNS tumours, most notably from schwannomas (sensitivity: 94%; specificity: 100%). Our results support the usefulness of combined SSR and conventional brain scintigraphy in the noninvasive pre-operative diagnosis of meningiomas. Springer-Verlag, 1996 [111In-DTPA-D-Phel]-octreotide nationallicence somatostatin receptors nationallicence meningioma nationallicence brain tumour nationallicence Barth A. Department of Neurosurgery, University of Berne, Inselspital, Berne, Switzerland aut Haldemann A. Department of Nuclear Medicine, University of Berne, Inselspital, Berne, Switzerland aut Reubi J. Institute of Pathology, University of Berne, Inselspital, Berne, Switzerland aut Godoy N. Department of Neurosurgery, University of Berne, Inselspital, Berne, Switzerland aut Rösier H. Department of Nuclear Medicine, University of Berne, Inselspital, Berne, Switzerland aut Kinser J. Department of Nuclear Medicine, University of Berne, Inselspital, Berne, Switzerland aut Seiler R. Department of Neurosurgery, University of Berne, Inselspital, Berne, Switzerland aut Acta Neurochirurgica Springer-Verlag 138/10(1996-10-01), 1179-1185 0001-6268 138:10<1179 1996 138 701 https://doi.org/10.1007/BF01809748 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01809748 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Barth A. Department of Neurosurgery, University of Berne, Inselspital, Berne, Switzerland aut NATIONALLICENCE 700 1- Haldemann A. Department of Nuclear Medicine, University of Berne, Inselspital, Berne, Switzerland aut NATIONALLICENCE 700 1- Reubi J. Institute of Pathology, University of Berne, Inselspital, Berne, Switzerland aut NATIONALLICENCE 700 1- Godoy N. Department of Neurosurgery, University of Berne, Inselspital, Berne, Switzerland aut NATIONALLICENCE 700 1- Rösier H. Department of Nuclear Medicine, University of Berne, Inselspital, Berne, Switzerland aut NATIONALLICENCE 700 1- Kinser J. Department of Nuclear Medicine, University of Berne, Inselspital, Berne, Switzerland aut NATIONALLICENCE 700 1- Seiler R. Department of Neurosurgery, University of Berne, Inselspital, Berne, Switzerland aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/10(1996-10-01), 1179-1185 0001-6268 138:10<1179 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer