caa a22 4500 477107818 CHVBK 20180405111600.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF01420309 doi (NATIONALLICENCE)springer-10.1007/BF01420309 Angiotensin II receptor content within the subfornical organ and organum vasculosum lamina terminalis increases after experimental subarachnoid haemorrhage in rats [Elektronische Daten] [B. Açikgöz, T. Özgen, F. Özdoğan, A. Sungur, İ. Tekkök] Summary: Nests of cells within the central nervous system, namely the circumventricular organs (CVOs) which include the subfornical organ (SFO), organum vasculosum lamina terminalis (OVLT), area postrema (AP) and the median eminence (ME) are known to contain not only receptors for angiotensin II (ANG II) but also ANG II itself. Though the significance of this central ANG II network in the pathophysiology of certain conditions like hypertension is well established, there appears to be a lack of knowledge as to how this system might be involved after subarachnoid haemorrhage (SAH). In this study, we have investigated ANG II receptor content change at various circumventricular organs after experimental subarachnoid haemorrhage in rats using a transcervical transclivai model. ANG II receptor content was detected by in vivo autoradiography using intracisternal ANG II Sar 1, Ile 8 labelled with iodine (I) 125 both at 30 minutes and 48 hours after the SAH. Serum angiotensin converting enzyme activity was also detected during the time course reflecting the involvement of the peripheral angiotensin system and showed an early rise and a fall after two days. Immunohistochemistry was utilized to show the ANG II-containing cells within the circumventricular organs. SFO and OVLT were found to have a statistically significant increase in ANG II receptor content persisting over two days after the SAH. These alterations in the receptor content of CVOs may indicate their possible role in delayed ischaemic deficits seen after SAH. Springer-Verlag, 1996 Angiotension II nationallicence autoradiography nationallicence brain nationallicence rat nationallicence receptors nationallicence subarachnoid haemorrhage nationallicence Açikgöz B. Department of Neurosurgery, Hacettepe University School of Medicine, Turkey aut Özgen T. Department of Neurosurgery, Hacettepe University School of Medicine, Turkey aut Özdoğan F. Refik Saydam Hifsizsihha Institution, Sihhiye, Ankara, Turkey aut Sungur A. Department of Pathology, Hacettepe University School of Medicine, Turkey aut Tekkök İ. Institute of Neurological Sciences, Hacettepe University, Turkey aut Acta Neurochirurgica Springer-Verlag 138/4(1996-04-01), 460-465 0001-6268 138:4<460 1996 138 701 https://doi.org/10.1007/BF01420309 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01420309 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Açikgöz B. Department of Neurosurgery, Hacettepe University School of Medicine, Turkey aut NATIONALLICENCE 700 1- Özgen T. Department of Neurosurgery, Hacettepe University School of Medicine, Turkey aut NATIONALLICENCE 700 1- Özdoğan F. Refik Saydam Hifsizsihha Institution, Sihhiye, Ankara, Turkey aut NATIONALLICENCE 700 1- Sungur A. Department of Pathology, Hacettepe University School of Medicine, Turkey aut NATIONALLICENCE 700 1- Tekkök İ. Institute of Neurological Sciences, Hacettepe University, Turkey aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/4(1996-04-01), 460-465 0001-6268 138:4<460 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer