caa a22 4500 477107826 CHVBK 20180405111600.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF01420304 doi (NATIONALLICENCE)springer-10.1007/BF01420304 Dexamethasone and colchicine reduce inflammation and delayed oedema following experimental brain contusion [Elektronische Daten] [S. Holmin, T. Mathiesen] Summary: The effect of anti-inflammatory treatment on monocyte/macrophage infiltration, major histocompatibility complex molecules (MHC) class II expression and delayed oedema following experimental brain contusion was studied by immunohistochemistry and tissue-specific gravity measurement in 44 rats. Colchicine, chloroquine and dexamethasone administered once daily for five days after the trauma reduced inflammation and oedema. The difference was statistically significant with colchicine and dexamethasone. The findings comprise further evidence of a pathogenetically important inflammation after experimental contusion. It is probable that anti-inflammatory agents may prevent secondary neurological damage due to elevated intracranial pressure and cell to cell- or cytokine-mediated neuronal degeneration and demyelination. Springer-Verlag, 1996 CNS trauma nationallicence experimental contusion nationallicence inflammation nationallicence brain oedema nationallicence Holmin S. Department of Clinical Neuroscience, Section of Neurosurgery, Karolinska Institute, Stockholm, Sweden aut Mathiesen T. Department of Clinical Neuroscience, Section of Neurosurgery, Karolinska Institute, Stockholm, Sweden aut Acta Neurochirurgica Springer-Verlag 138/4(1996-04-01), 418-424 0001-6268 138:4<418 1996 138 701 https://doi.org/10.1007/BF01420304 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01420304 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Holmin S. Department of Clinical Neuroscience, Section of Neurosurgery, Karolinska Institute, Stockholm, Sweden aut NATIONALLICENCE 700 1- Mathiesen T. Department of Clinical Neuroscience, Section of Neurosurgery, Karolinska Institute, Stockholm, Sweden aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/4(1996-04-01), 418-424 0001-6268 138:4<418 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer