caa a22 4500 47710794X CHVBK 20180405111600.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF01420300 doi (NATIONALLICENCE)springer-10.1007/BF01420300 Type IV collagenase activity and cavernous sinus invasion in human pituitary adenomas [Elektronische Daten] [H. Kawamoto, T. Uozumi, K. Kawamoto, K. Arita, T. Yano, T. Hirohata] Summary: Pituitary adenomas are regarded generally as benign tumours, but some of them can invade the cavernous sinus. On the other hand, matrix metalloproteinase-9 (MMP-9), which is a type IV collagenase, recently has been found to be expressed in matastases and to be related to the invasiveness of various malignant tumours including brain tumours. In order to investigate some characteristic features of pituitary adenomas which invade the cavernous sinus, we examined immunohistological studies for MMP-9 in seven pituitary adenomas for type IV collagen in a dura mater and assayed for type IV collagenase activity in seven adenomas using type IV collagen labelled with fluorescein isothiocyaniate (FITC). We found immunopositive adenoma cells for MMP-9 in all invasive adenoma and immunopositive spindle like cells for type IV collagen in the dura mater. All three invasive adenomas had high levels of type IV collagenase activity (0.57-0.72 U/ml), but the four adenomas which did not invade the cavernous sinus had low levels of type IV collagenase activity (0.0-0.10 U/ml). These results suggest that the level of type IV collagenase activity in a pituitary adenoma may be related to its ability to invade the cavernous sinus. Springer-Verlag, 1996 Cavernous sinus invasion nationallicence pituitary adenomas nationallicence type IV collagenase nationallicence Kawamoto H. Department of Neurosurgery, Hiroshima University School of Medicine, Hiroshima aut Uozumi T. Department of Neurosurgery, Hiroshima University School of Medicine, Hiroshima aut Kawamoto K. Department of Biology, Toyama University Faculty of Biology, Toyama, Japan aut Arita K. Department of Neurosurgery, Hiroshima University School of Medicine, Hiroshima aut Yano T. Department of Neurosurgery, Hiroshima University School of Medicine, Hiroshima aut Hirohata T. Department of Neurosurgery, Hiroshima University School of Medicine, Hiroshima aut Acta Neurochirurgica Springer-Verlag 138/4(1996-04-01), 390-395 0001-6268 138:4<390 1996 138 701 https://doi.org/10.1007/BF01420300 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01420300 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kawamoto H. Department of Neurosurgery, Hiroshima University School of Medicine, Hiroshima aut NATIONALLICENCE 700 1- Uozumi T. Department of Neurosurgery, Hiroshima University School of Medicine, Hiroshima aut NATIONALLICENCE 700 1- Kawamoto K. Department of Biology, Toyama University Faculty of Biology, Toyama, Japan aut NATIONALLICENCE 700 1- Arita K. Department of Neurosurgery, Hiroshima University School of Medicine, Hiroshima aut NATIONALLICENCE 700 1- Yano T. Department of Neurosurgery, Hiroshima University School of Medicine, Hiroshima aut NATIONALLICENCE 700 1- Hirohata T. Department of Neurosurgery, Hiroshima University School of Medicine, Hiroshima aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/4(1996-04-01), 390-395 0001-6268 138:4<390 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer