caa a22 4500 477108075 CHVBK 20180405111601.0 cr unu---uuuuu 170330e19960801xx s 000 0 eng 10.1007/BF01411287 doi (NATIONALLICENCE)springer-10.1007/BF01411287 Changes in serum cytokine concentrations after neurosurgical procedures [Elektronische Daten] [K. Osuka, Y. Suzuki, K. Saito, M. Takayasu, M. Shibuya] Summary: Cytokine responses to surgical trauma have been studied in 70 patients undergoing various neurosurgical procedures. Serum concentrations of interleukin-1ß (IL-1ß), interleukin-6 (IL-6), interleukin-8, (IL-8), tumour necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were measured before and after surgery using enzyme-linked immunosorbent assays. The serum concentrations of IL-1ß, IL-8, TNF-α, and IFN-γ did not change significantly following neurosurgical operations. In contrast, serum IL-6 levels were significantly elevated following surgery, peaking at postoperative day 1 and then gradually decreasing. Maximum IL-6 concentrations were considerably higher in patients who underwent surgery for brain tumours or aneurysms as compared with patients who had a ventriculoperitoneal shunt, neurovascular decompression or transsphenoidal adenomectomy. Intra-operative use of methylprednisolone, which is known to block the production and action of cytokines, suppressed the increase in IL-6 levels after surgery. There was a statistically significant correlation between the IL-6 peak concentration and the length of surgery in patients not treated with steroids, but not in patients treated with steroids. Additionally patients who underwent supratentorial surgery had higher peak concentrations of IL-6 than those who underwent infratentorial surgery. These results suggest that IL-6 is an early marker of tissue damage and may be useful in assessing the extent of postoperative stress. Springer-Verlag, 1996 Cytokine nationallicence interleukin-6, neurosurgery nationallicence steroid nationallicence Osuka K. Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan aut Suzuki Y. Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan aut Saito K. Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan aut Takayasu M. Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan aut Shibuya M. Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan aut Acta Neurochirurgica Springer-Verlag 138/8(1996-08-01), 970-976 0001-6268 138:8<970 1996 138 701 https://doi.org/10.1007/BF01411287 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411287 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Osuka K. Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Suzuki Y. Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Saito K. Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Takayasu M. Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Shibuya M. Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/8(1996-08-01), 970-976 0001-6268 138:8<970 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer