caa a22 4500 477108199 CHVBK 20180405111601.0 cr unu---uuuuu 170330e19960801xx s 000 0 eng 10.1007/BF01411291 doi (NATIONALLICENCE)springer-10.1007/BF01411291 A Case of pituitary somatotroph adenoma with concomitant secretion of growth hormone, prolactin, and adrenocorticotropic hormone — an adenoma derived from primordial stem cell, studied by immunohistochemistry, in situ hybridization, and cell culture [Elektronische Daten] [A. Matsuno, T. Sasaki, T. Mochizuki, T. Fujimaki, N. Sanno, Y. Osamura, A. Teramoto, T. Kirino] Summary: Somatotroph adenomas often secrete prolactin (PRL) besides growth hormone (GH) and are sometimes immunostained for other anterior pituitary hormones or their subunits, such as thyroid-stimulating hormone (TSH) β-subunit and glycoprotein hormone α-subunit (αSU). However, Somatotroph adenomas showing hypersecretion of adrenocorticotropic hormone (ACTH) are extremely rare. There have been, to our knowledge, only five published reports on Somatotroph adenomas accompanied by excessive ACTH secretion. Here we report a case of intracavernously invading Somatotroph macro-adenoma with high serum GH, PRL, and ACTH levels. We examined the case using immunohistochemistry (IHC), in situ hybridization (ISH), and cell culture, and confirmed GH, PRL, and ACTH, as well as αSU, production, and the expression of Pit-1 protein by the adenoma, which is known as a transcriptional factor for GH, PRL, and TSH, not for ACTH. Therefore, the presence of unknown transcriptional factor other than Pit-1, common to GH, PRL, and ACTH, may be speculated to be expressed in this adenoma. In our previous study, we had found plurihormonal mRNA expression, especially for ACTH, the β-subunit of follicle-stimulating hormone and luteinizing hormone in some Somatotroph adenomas, using non-radio-isotopic ISH, and suggested that these adenomas might be derived from plurihormonal primordial stem cells. Our present case is significant from the viewpoint of histogenesis of pituitary adenomas, because it further supports the cell origin of Somatotroph adenomas from plurihormonal primordial stem cells, and moreover it suggests the presence of unknown transcriptional factor other than Pit-1, common to GH, PRL, and ACTH. Springer-Verlag, 1996 Adrenocorticotropic hormone nationallicence hypersecretion nationallicence plurihormonal primordial stem cell nationallicence Somatotroph adenoma nationallicence Matsuno A. Department of Neurosurgery, University of Tokyo Hospital, Hongo, Bunkyo-ku, Tokyo aut Sasaki T. Department of Neurosurgery, University of Tokyo Hospital, Hongo, Bunkyo-ku, Tokyo aut Mochizuki T. Department of Neurosurgery, University of Tokyo Hospital, Hongo, Bunkyo-ku, Tokyo aut Fujimaki T. Department of Pathology, Tokai University School of Medicine, Boseidai, Isehara City, Kanagawa aut Sanno N. Department of Pathology, Tokai University School of Medicine, Boseidai, Isehara City, Kanagawa aut Osamura Y. Department of Pathology, Tokai University School of Medicine, Boseidai, Isehara City, Kanagawa aut Teramoto A. Department of Neurosurgery, Nippon Medical School, Sendagi, Bunkyo-ku, Tokyo, Japan aut Kirino T. Department of Neurosurgery, University of Tokyo Hospital, Hongo, Bunkyo-ku, Tokyo aut Acta Neurochirurgica Springer-Verlag 138/8(1996-08-01), 1002-1007 0001-6268 138:8<1002 1996 138 701 https://doi.org/10.1007/BF01411291 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411291 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Matsuno A. Department of Neurosurgery, University of Tokyo Hospital, Hongo, Bunkyo-ku, Tokyo aut NATIONALLICENCE 700 1- Sasaki T. Department of Neurosurgery, University of Tokyo Hospital, Hongo, Bunkyo-ku, Tokyo aut NATIONALLICENCE 700 1- Mochizuki T. Department of Neurosurgery, University of Tokyo Hospital, Hongo, Bunkyo-ku, Tokyo aut NATIONALLICENCE 700 1- Fujimaki T. Department of Pathology, Tokai University School of Medicine, Boseidai, Isehara City, Kanagawa aut NATIONALLICENCE 700 1- Sanno N. Department of Pathology, Tokai University School of Medicine, Boseidai, Isehara City, Kanagawa aut NATIONALLICENCE 700 1- Osamura Y. Department of Pathology, Tokai University School of Medicine, Boseidai, Isehara City, Kanagawa aut NATIONALLICENCE 700 1- Teramoto A. Department of Neurosurgery, Nippon Medical School, Sendagi, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Kirino T. Department of Neurosurgery, University of Tokyo Hospital, Hongo, Bunkyo-ku, Tokyo aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/8(1996-08-01), 1002-1007 0001-6268 138:8<1002 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer