caa a22 4500 477108202 CHVBK 20180405111601.0 cr unu---uuuuu 170330e19960801xx s 000 0 eng 10.1007/BF01411280 doi (NATIONALLICENCE)springer-10.1007/BF01411280 Water and sodium disorders following surgical excision of pituitary region tumours [Elektronische Daten] [W. Poon, Y. Lolin, T. Yeung, C. Yip, K. Goh, M. Lam, C. Cockram] Summary: A prospective observational study of the pathophysiology of sodium and water disorders in patients with pituitary region tumours after surgical excision was carried out in 20 patients. Serial pre-operative and post-operative fluid and sodium balance, plasma and urine elctrolyte biochemistry and their derived parameters, and circulating hormones associated with fluid balance, atrial natriureic peptide (ANP) and antidiuretic hormone (ADH) were documented to correlate with the patients' clinical conditions. Ten out of these twenty cases developed diabetes insipidus (DI) requiring ADH replacement therapy, although in the majority (6 cases), this way only a transient event. Of the nine patients who developed hyponatraemia, six had symptoms such as impaired consciousness and convulsions. Four patients developed alternating hypoatraemia and hypernatraemia, which constituted a difficult group, where appropriate sodium and fluid management, and ADH replacement therapy were based upon twice daily plasma and urine biochemistry and their derived parameters. Whilst DI in this group of patients was the result of a low circulating ADH level, hyponatraemia was not associated with an exaggerated ADH activity (6.0 ± 2.3 vs 7.4 ± 2.3 pmol/ml, mean ± SEM). Rather, hyponatraemia was strongly associated with an elevated circulating ANP concentration (82.4±10.5 vs 30.0 ±3.1 pmol/ml, mean ± SEM, p < 0.001), resulting in salt wasting and hypovolaemia. Springer-Verlag, 1996 Diabetes insipidus nationallicence hyponatraemia nationallicence pituitary tumours nationallicence cerebral salt wasting nationallicence Poon W. Departments of Surgery (Neurosurgical Unit), Chemical Pathology, and Medicine, Prince of Wales Hospital, Shatin, Hong Kong aut Lolin Y. Departments of Surgery (Neurosurgical Unit), Chemical Pathology, and Medicine, Prince of Wales Hospital, Shatin, Hong Kong aut Yeung T. Departments of Surgery (Neurosurgical Unit), Chemical Pathology, and Medicine, Prince of Wales Hospital, Shatin, Hong Kong aut Yip C. Departments of Surgery (Neurosurgical Unit), Chemical Pathology, and Medicine, Prince of Wales Hospital, Shatin, Hong Kong aut Goh K. Departments of Surgery (Neurosurgical Unit), Chemical Pathology, and Medicine, Prince of Wales Hospital, Shatin, Hong Kong aut Lam M. Departments of Surgery (Neurosurgical Unit), Chemical Pathology, and Medicine, Prince of Wales Hospital, Shatin, Hong Kong aut Cockram C. Departments of Surgery (Neurosurgical Unit), Chemical Pathology, and Medicine, Prince of Wales Hospital, Shatin, Hong Kong aut Acta Neurochirurgica Springer-Verlag 138/8(1996-08-01), 921-927 0001-6268 138:8<921 1996 138 701 https://doi.org/10.1007/BF01411280 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411280 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Poon W. Departments of Surgery (Neurosurgical Unit), Chemical Pathology, and Medicine, Prince of Wales Hospital, Shatin, Hong Kong aut NATIONALLICENCE 700 1- Lolin Y. Departments of Surgery (Neurosurgical Unit), Chemical Pathology, and Medicine, Prince of Wales Hospital, Shatin, Hong Kong aut NATIONALLICENCE 700 1- Yeung T. Departments of Surgery (Neurosurgical Unit), Chemical Pathology, and Medicine, Prince of Wales Hospital, Shatin, Hong Kong aut NATIONALLICENCE 700 1- Yip C. Departments of Surgery (Neurosurgical Unit), Chemical Pathology, and Medicine, Prince of Wales Hospital, Shatin, Hong Kong aut NATIONALLICENCE 700 1- Goh K. Departments of Surgery (Neurosurgical Unit), Chemical Pathology, and Medicine, Prince of Wales Hospital, Shatin, Hong Kong aut NATIONALLICENCE 700 1- Lam M. Departments of Surgery (Neurosurgical Unit), Chemical Pathology, and Medicine, Prince of Wales Hospital, Shatin, Hong Kong aut NATIONALLICENCE 700 1- Cockram C. Departments of Surgery (Neurosurgical Unit), Chemical Pathology, and Medicine, Prince of Wales Hospital, Shatin, Hong Kong aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/8(1996-08-01), 921-927 0001-6268 138:8<921 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer