caa a22 4500 47710830X CHVBK 20180405111601.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF01411168 doi (NATIONALLICENCE)springer-10.1007/BF01411168 Proliferating cell nuclear antigen (PCNA) and Ki-67 immunopositivity in human astrocytic tumours [Elektronische Daten] [R. Kordek, W. Biernat, J. Alwasiak, P. Liberski] Summary: To compare the Ki-67 and Proliferating Cell Nuclear Antigen (PCNA), markers of cell proliferation, paraffin embedded surgical specimens from 56 human astrocytic tumours (8 pilocytic tumours, grade I; 9 low (II) grade and 9 anaplastic (grade III) astrocytomas and 30 glioblastomas, grade IV) were immunolabelled with the anti-PCNA (PC 10, DAKO) and anti-Ki-67 (DAKO) antibodies. For the latter immunostaining the microwave oven processing was performed. The Ki-67 and PCNA labelling indices (LIs) were statistically compared. For the majority of cases, PCNA LI was higher than that obtained with anti-Ki-67 antibody and the intensity of staining for PCNA was more variable. The statistically significant difference of the percentage of PCNA LIs was found only between low grade (I and II) and high grade (III and IV) tumours, while Ki-67 LIs discriminates each group of glial tumours; thus this latter marker is more sensitive and specific. Springer-Verlag, 1996 Astrocytoma nationallicence Ki-67 nationallicence proliferating cell nuclear antigen nationallicence Kordek R. Department of Pathology, Chair of Oncology, Medical University of Lódź, Poland aut Biernat W. Department of Pathology, Chair of Oncology, Medical University of Lódź, Poland aut Alwasiak J. Department of Pathology, Chair of Oncology, Medical University of Lódź, Poland aut Liberski P. Laboratory of Electron Microscopy and Neuropathology, Laboratories of Tumour Biology, Chair of Oncology, Medical University of Lódź, Poland aut Acta Neurochirurgica Springer-Verlag 138/5(1996-05-01), 509-513 0001-6268 138:5<509 1996 138 701 https://doi.org/10.1007/BF01411168 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411168 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kordek R. Department of Pathology, Chair of Oncology, Medical University of Lódź, Poland aut NATIONALLICENCE 700 1- Biernat W. Department of Pathology, Chair of Oncology, Medical University of Lódź, Poland aut NATIONALLICENCE 700 1- Alwasiak J. Department of Pathology, Chair of Oncology, Medical University of Lódź, Poland aut NATIONALLICENCE 700 1- Liberski P. Laboratory of Electron Microscopy and Neuropathology, Laboratories of Tumour Biology, Chair of Oncology, Medical University of Lódź, Poland aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/5(1996-05-01), 509-513 0001-6268 138:5<509 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer