caa a22 4500 477108423 CHVBK 20180405111602.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF01411166 doi (NATIONALLICENCE)springer-10.1007/BF01411166 Brain oedema in patients with intracranial meningioma [Elektronische Daten] Correlation between clinical, radiological, and histological factors and the presence and intensity of oedema [R. Lobato, R. Alday, P. Gómez, J. Rivas, J. Domínguez, A. Cabrera, S. Madero, J. Ayerbe] Summary: The authors analysed the correlation between different clinical, radiological, and pathological variables and the presence and intensity of brain oedema associated to intracranial meningioma in 400 consecutive patients studied by computerized tomography (CT). The following factors did not show significant correlation with brain oedema development: the age and sex of the patient, the occurrence of focal deficits, the presence of skull changes (endostosis, exostosis, osteolysis), the occurrence of tumour calcification, the density of the tumour on plain CT scan, the presence of a cystic component, the pathological subtype of meningioma (both conventional and non-conventional), and the presence of histological features of tumour aggressiveness, such as an increased vascularization, high cellularity, high mitotic index, pleomorphism, necrosis, and brain infiltration. Factors showing a statistically significant correlation with the presence and intensity of brain oedema at the bivariate analysis were: the presence of symptoms (p < 0.001), the duration of the clinical history (p < 0.05), the location and size of the tumour (p < 0.001), the type (heterogeneous vs homogeneous), and intensity of tumour contrast enhancement (p < 0.001), the presence of irregular tumour margins (p < 0.001), and the existence of focal low density intratumoural areas (p < 0.001). The multivariate analysis using only clinical parameters showed that the group of variables with the highest power for predicting the presence of brain oedema (concordance level of 76.8%) included: the presence of symptoms, the occurrence of seizures (focal or generalized), the presence of an intracranial hypertension syndrome, and the age of the patient. The multivariate analysis using only anatomico-radiological parameters showed that the model which included the size of the tumour, the intensity of contrast enhancement, the tumour margins, and meningioma location, predicted the presence of brain oedema in 80.8% of the cases. Though the results of the present study do not definitively support any of the major physiopathological theories proposed to explain brain oedema formation in patients with intracranial meningioma, some findings could favour the so-called hydrodynamic theory. Springer-Verlag, 1996 Brain oedema nationallicence computerized tomography nationallicence intracranial hypertension nationallicence intracranial meningioma nationallicence seizures nationallicence Lobato R. Service of Neurosurgery, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut Alday R. Service of Neurosurgery, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut Gómez P. Service of Neurosurgery, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut Rivas J. Service of Neurosurgery, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut Domínguez J. Service of Neurosurgery, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut Cabrera A. Service of Neurosurgery, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut Madero S. Section of Neuropathology, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut Ayerbe J. Service of Neurosurgery, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut Acta Neurochirurgica Springer-Verlag 138/5(1996-05-01), 485-494 0001-6268 138:5<485 1996 138 701 https://doi.org/10.1007/BF01411166 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411166 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lobato R. Service of Neurosurgery, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut NATIONALLICENCE 700 1- Alday R. Service of Neurosurgery, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut NATIONALLICENCE 700 1- Gómez P. Service of Neurosurgery, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut NATIONALLICENCE 700 1- Rivas J. Service of Neurosurgery, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut NATIONALLICENCE 700 1- Domínguez J. Service of Neurosurgery, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut NATIONALLICENCE 700 1- Cabrera A. Service of Neurosurgery, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut NATIONALLICENCE 700 1- Madero S. Section of Neuropathology, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut NATIONALLICENCE 700 1- Ayerbe J. Service of Neurosurgery, Hospital "12 de Octubre”, and Facultad de Medicina, Universidad Complutense, Madrid, Spain aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/5(1996-05-01), 485-494 0001-6268 138:5<485 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer