caa a22 4500 477108466 CHVBK 20180405111602.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF01411364 doi (NATIONALLICENCE)springer-10.1007/BF01411364 Intravenous administration of high doses of carboplatin in multimodal treatment of high grade gliomas: a phase II study [Elektronische Daten] [P. Lunardi, J. Osman Farah, L. Mastronardi, F. Puzzilli, F. Lo Bianco] Summary: The object of this study is to evaluate the efficacy of a high dose of carboplatin in 20 patients operated on for high grade glioma (Group A) compared with a matched control (Group B) treated with BCNU administered after radiotherapy. The toxicity profile has been evaluated during the therapy. The survival of patients entering this study was measured in terms of months: the mean survival time was 10.45 months and the median 11.0 months in the — group treated with carboplatin (8 patients are still alive); the 18-month survival rate was 10%. The mean survival time of the control group was 9.85 months and the median 10.5 months; no patients are still alive and the 18-month survival rate was 0%. On the basis of our phase II clinical study, we could conclude that i.v. administration of high-doses of carboplatin in high grade gliomas is generally well tolerated and the results are better than those of a matched control treated with 1-2 courses of BCNU (low-dose). The adjuvant treatment and the role of carboplatin in the therapy of high grade gliomas is discussed. Springer-Verlag, 1996 Carboplatin nationallicence cerebral gliomas nationallicence chemotherapy nationallicence nitrosurea nationallicence Lunardi P. Department of Neurological Sciences, University of Rome "La Sapienza”, 2nd Chair of Neurosurgery, Rome, Italy aut Osman Farah J. Department of Neurological Sciences, University of Rome "La Sapienza”, 2nd Chair of Neurosurgery, Rome, Italy aut Mastronardi L. Department of Neurological Sciences, University of Rome "La Sapienza”, 2nd Chair of Neurosurgery, Rome, Italy aut Puzzilli F. Department of Neurological Sciences, University of Rome "La Sapienza”, 2nd Chair of Neurosurgery, Rome, Italy aut Lo Bianco F. Department of Neurological Sciences, University of Rome "La Sapienza”, 2nd Chair of Neurosurgery, Rome, Italy aut Acta Neurochirurgica Springer-Verlag 138/2(1996-02-01), 215-220 0001-6268 138:2<215 1996 138 701 https://doi.org/10.1007/BF01411364 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411364 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lunardi P. Department of Neurological Sciences, University of Rome "La Sapienza”, 2nd Chair of Neurosurgery, Rome, Italy aut NATIONALLICENCE 700 1- Osman Farah J. Department of Neurological Sciences, University of Rome "La Sapienza”, 2nd Chair of Neurosurgery, Rome, Italy aut NATIONALLICENCE 700 1- Mastronardi L. Department of Neurological Sciences, University of Rome "La Sapienza”, 2nd Chair of Neurosurgery, Rome, Italy aut NATIONALLICENCE 700 1- Puzzilli F. Department of Neurological Sciences, University of Rome "La Sapienza”, 2nd Chair of Neurosurgery, Rome, Italy aut NATIONALLICENCE 700 1- Lo Bianco F. Department of Neurological Sciences, University of Rome "La Sapienza”, 2nd Chair of Neurosurgery, Rome, Italy aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/2(1996-02-01), 215-220 0001-6268 138:2<215 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer