caa a22 4500 477108784 CHVBK 20180405111603.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF01411065 doi (NATIONALLICENCE)springer-10.1007/BF01411065 Histological heterogeneity of neuroradiologically suspected adult low grade gliomas detected by Xenon enhanced computerized tomography (CT) [Elektronische Daten] [K. Roessler, C. Nasel, T. Czech, Ch. Matula, H. Lassmann, W. Koos] Summary: Xenon-enhanced computerized tomography (XeCT) was performed on 14 consecutive adult patients presenting with seizures showing supratentorial non-enhancing radiologically uniform appearing low grade gliomas on CT/MR images. Pre-operative XeCT patterns were compared with postoperative histological diagnosis, grading and Ki67 proliferation indices (PI). After gross-total, subtotal resection or biopsy, 11 astrocytomas, 2 oligodendrogliomas and 1 oligo-astrocytoma were diagnosed and graded: Grade I: 2 patients (Ki67-PI=0.5-0.8), Grade I-II: 4 patients (Ki67-PI=0.3-1.5), Grade II: 3 patients (Ki67-PI=0.5-3.5), Grade II-III: 4 patients (Ki67-PI=3.8-6.8) and Grade III: 1 patient (Ki67-PI=5.2), (Kernohan Classification). Xenon CT studies revealed different flow patterns, correlating with the postoperative histological diagnosis, grading and proliferation indices: A tumour group with well defined, delayed, only minimally enhancing tumour area (5 patients, Grade I, I-II or II), a second group with less well defined low-flow-area borders and inhomogenous, strong enhancement within the tumour (4 patients, Grade II-III, III) and a third group with fast enhancing tumours was identified. The third pattern was exclusively shown in the 2 oligodendrogliomas (Grade I and II-III) and 1 oligo-astrocytoma (Grade II). The preliminary report identifies the Xenon enhanced CT as a beneficial pre-operative investigation for patients with radiologically uniform appearing suspected adult supratentorial low-grade gliomas, which may give information about the presence of anaplastic foci or oligodendroglial components. Springer-Verlag, 1996 Low grade gliomas nationallicence Xenon CT nationallicence stereotactic biopsy nationallicence histological grading nationallicence Roessler K. Department of Neurosurgery, University of Vienna Medical School, Austria aut Nasel C. Department of Neuroradiology, University of Vienna Medical School, Austria aut Czech T. Department of Neurosurgery, University of Vienna Medical School, Austria aut Matula Ch Department of Neurosurgery, University of Vienna Medical School, Austria aut Lassmann H. Research Unit for Experimental Neuropathology, Austrian Academy of Sciences, Vienna, Austria aut Koos W. Department of Neurosurgery, University of Vienna Medical School, Austria aut Acta Neurochirurgica Springer-Verlag 138/11(1996-11-01), 1341-1347 0001-6268 138:11<1341 1996 138 701 https://doi.org/10.1007/BF01411065 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01411065 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Roessler K. Department of Neurosurgery, University of Vienna Medical School, Austria aut NATIONALLICENCE 700 1- Nasel C. Department of Neuroradiology, University of Vienna Medical School, Austria aut NATIONALLICENCE 700 1- Czech T. Department of Neurosurgery, University of Vienna Medical School, Austria aut NATIONALLICENCE 700 1- Matula Ch Department of Neurosurgery, University of Vienna Medical School, Austria aut NATIONALLICENCE 700 1- Lassmann H. Research Unit for Experimental Neuropathology, Austrian Academy of Sciences, Vienna, Austria aut NATIONALLICENCE 700 1- Koos W. Department of Neurosurgery, University of Vienna Medical School, Austria aut NATIONALLICENCE 773 0- Acta Neurochirurgica Springer-Verlag 138/11(1996-11-01), 1341-1347 0001-6268 138:11<1341 1996 138 701 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer