caa a22 4500 477112587 CHVBK 20180405111613.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01744599 doi (NATIONALLICENCE)springer-10.1007/BF01744599 Theoretical treatment of striated muscle: Dynamic extension of four-state model [Elektronische Daten] [Hideyuki Honda, Yoshiro Koiwa, Kunio Shirato] Summary: We constructed a muscle model, based on the model first proposed by Gray and Gonda [6,7], that simulates the twitch contraction of striated muscle. Their original model postulated four basic states in the contraction cycle and predicted the properties of steady state contraction in striated muscle. Using the relationship between steady state tension and calcium concentration, we described several rate constants as functions of calcium concentration and calculated the number of attached crossbridges at various calcium concentration values. The results for both skeletal and cardiac muscle were approximately consistent with those of X-ray studies. Assuming that rate constants change immediately with the phasic alteration of intracellular calcium concentration, we estimated the time course of crossbridge distribution during twitch contraction; these findings were also consistent with those of X-ray studies. We also simulated the effects of calcium concentration and sarcomere length on the magnitude of twitch tension. These simulations suggest that the major determinants of crossbridge distribution during twitch contraction are the time courses of calcium transients and the rate constants of crossbridge kinetics. Our findings suggest that the model used in this study provides a theoretical basis for interpreting the characteristics of cardiac muscle encountered in the clinical setting. Springer-Verlag, 1996 Muscle model nationallicence Crossbridge kinetics nationallicence Striated muscle nationallicence Honda Hideyuki First Department of Internal Medicine, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-71, Sendai, Japan aut Koiwa Yoshiro First Department of Internal Medicine, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-71, Sendai, Japan aut Shirato Kunio First Department of Internal Medicine, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-71, Sendai, Japan aut Heart and Vessels Springer-Verlag 11/1(1996-01-01), 44-53 0910-8327 11:1<44 1996 11 380 https://doi.org/10.1007/BF01744599 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01744599 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Honda Hideyuki First Department of Internal Medicine, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-71, Sendai, Japan aut NATIONALLICENCE 700 1- Koiwa Yoshiro First Department of Internal Medicine, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-71, Sendai, Japan aut NATIONALLICENCE 700 1- Shirato Kunio First Department of Internal Medicine, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-71, Sendai, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer-Verlag 11/1(1996-01-01), 44-53 0910-8327 11:1<44 1996 11 380 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer