caa a22 4500 477112617 CHVBK 20180405111613.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01744595 doi (NATIONALLICENCE)springer-10.1007/BF01744595 Responses to mechanical stimuli of isolated basilar and femoral arteries of the rhesus monkey are different [Elektronische Daten] [Pieter Sipkema, Peter van der Linden, John Fanton, Ricky Latham] Summary: The present study aimed to determine regional differences in diameter response to mechanical stimuli such as flow (shear stress) and transmural pressure (myogenic response) of the isolated basilar artery and femoral artery from Rhesus monkeys. Whether or not spontaneous tone developed, a transmural pressure-diameter relation was determined after the equilibration period. Vessels were then constricted with a submaximal dose of prostaglandin-F2α (PGF2α; 1.23-2µM) and a flow-diameter relation (0-2,000µl/min) and a pressure-diameter (15-125cmH2O) relation were determined. Endothelium function was tested with the calcium ionophore A-23187 (1.0 µM). The vessels were then maximally dilated (papaverine, 100µM) and a passive pressure-diameter relation was determined. The responses of the basilar and the femoral arteries were markedly different. The basilar artery developed spontaneous tone, while the femoral artery did not. The basilar artery showed flow-induced constriction (P = 0.024), while the femoral artery dilated when flow was increased (P = 0.0005). The myogenic index of the two arteries during treatment with PGF2α was not different (P = 0.49) and the strength of the myogenic response was such that the diameter of both arteries stayed constant over the pressure range studied. We conclude that the responses to mechanical stimuli of the basilar artery and the femoral artery of the Rhesus monkey are markedly different. Springer-Verlag, 1996 Prostaglandin-F2α nationallicence Myogenic response nationallicence Spontaneous tone nationallicence Flow-induced dilation nationallicence Flow-induced constriction nationallicence Myogenic index nationallicence Macaca mulatta nationallicence Sipkema Pieter Laboratory for Physiology, ICaR-VU, Free University, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands aut van der Linden Peter Laboratory for Physiology, ICaR-VU, Free University, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands aut Fanton John Armstrong Laboratory, Brooks Air Force Base, San Antonio, TX, USA aut Latham Ricky Armstrong Laboratory, Brooks Air Force Base, San Antonio, TX, USA aut Heart and Vessels Springer-Verlag 11/1(1996-01-01), 18-26 0910-8327 11:1<18 1996 11 380 https://doi.org/10.1007/BF01744595 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01744595 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sipkema Pieter Laboratory for Physiology, ICaR-VU, Free University, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van der Linden Peter Laboratory for Physiology, ICaR-VU, Free University, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Fanton John Armstrong Laboratory, Brooks Air Force Base, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Latham Ricky Armstrong Laboratory, Brooks Air Force Base, San Antonio, TX, USA aut NATIONALLICENCE 773 0- Heart and Vessels Springer-Verlag 11/1(1996-01-01), 18-26 0910-8327 11:1<18 1996 11 380 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer