caa a22 4500 477112625 CHVBK 20180405111614.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01744593 doi (NATIONALLICENCE)springer-10.1007/BF01744593 Lack of vasodilatory response in skeletal muscle blood vessels of aged spontaneously hypertensive rats [Elektronische Daten] [Kunisuke Horiuchi, Hong He, Atsufumi Tomohiro, Yasuharu Aki, Shoji Kimura, Toshiaki Tamaki, Youichi Abe] Summary: Regional hemodynamic responses to the vasodilators, hydralazine (1mg/kg, i.v.) and verapamil (0.1 mg/kg/min, i.v.), were examined in conscious Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR), 15 and 50 weeks of age, using the radioactive microsphere method. The flow rates of heart and skeletal muscle in SHR were higher than those in WKY, and the flow rates of liver, kidney, intestines, and skin in SHR were lower than those in WKY. These differences between the regional blood flow in WKY and SHR were observed in both aged and young rats. The changes in organ blood flow induced by hydralazine and verapamil were similar for WKY and SHR in most organs. Both drugs increased the skeletal muscle blood flow in WKY and young SHR, but not in aged SHR, that is, the skeletal muscle blood vessels in aged SHR lost their vasodilatory response. These results suggest that, although a lack of vasodilatory responses in the skeletal muscle vasculature of aged SHR may be triggered by persistent hypertension, the vital organ vasculature maintains its normal vasodilating capacity. Springer-Verlag, 1996 Regional hemodynamics nationallicence Hydralazine nationallicence Verapamil nationallicence Skeletal muscle nationallicence Ageing nationallicence Horiuchi Kunisuke Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, 761-07, Kagawa, Japan aut He Hong Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, 761-07, Kagawa, Japan aut Tomohiro Atsufumi Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, 761-07, Kagawa, Japan aut Aki Yasuharu Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, 761-07, Kagawa, Japan aut Kimura Shoji Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, 761-07, Kagawa, Japan aut Tamaki Toshiaki Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, 761-07, Kagawa, Japan aut Abe Youichi Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, 761-07, Kagawa, Japan aut Heart and Vessels Springer-Verlag 11/1(1996-01-01), 1-9 0910-8327 11:1<1 1996 11 380 https://doi.org/10.1007/BF01744593 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01744593 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Horiuchi Kunisuke Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, 761-07, Kagawa, Japan aut NATIONALLICENCE 700 1- He Hong Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, 761-07, Kagawa, Japan aut NATIONALLICENCE 700 1- Tomohiro Atsufumi Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, 761-07, Kagawa, Japan aut NATIONALLICENCE 700 1- Aki Yasuharu Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, 761-07, Kagawa, Japan aut NATIONALLICENCE 700 1- Kimura Shoji Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, 761-07, Kagawa, Japan aut NATIONALLICENCE 700 1- Tamaki Toshiaki Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, 761-07, Kagawa, Japan aut NATIONALLICENCE 700 1- Abe Youichi Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, 761-07, Kagawa, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer-Verlag 11/1(1996-01-01), 1-9 0910-8327 11:1<1 1996 11 380 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer