caa a22 4500 477112641 CHVBK 20180405111614.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF01747186 doi (NATIONALLICENCE)springer-10.1007/BF01747186 HLA-DR6 (possibly DRB1*1301) is associated with susceptibility to Takayasu arteritis in Mexicans [Elektronische Daten] [Eduardo Girona, Jesús Yamamoto-Furusho, Teresa Cutiño, Pedro Reyes, Gilberto Vargas-Alarcón, Julio Granados, Donato Alarcón-Segovia] Summary: Takayasu arteritis is characterized by a "pulseless” condition and occurs frequently in young females from Asian and South American countries. This disease has been found to be linked with major histocompatibility complex (MHC) antigens in Japanese individuals. In the present study we compared gene frequencies of class I, class II, and class III MHC genotypes in patients with Takayasu arteritis and ethnically matched healthy controls. Serological typing was confirmed by molecular typing at the DNA level. We found significant increases in the frequencies of human leucocyte antigen (HLA)-DR6 and HLA-B62 in patients compared to the healthy controls (P corrected [C] = 0.0007, relative risk [RR] = 5.08;PC = 0.05, RR = 3.13 respectively). However, since the number of patients was considerably lower than the number of controls this can be considered as a tendency and not a true association. On the other hand, we found a significantly decreased frequency of HLA-DR4 in patients compared to healthy controls (PC = 0.04, RR = 0.34). At the DNA level, all DR6-positive individuals were HLA-DRB1*1301 whereas controls were HLA-DRB1*1301 (4.2%). Takayasu arteritis in Mexicans is probably associated with the HLA-DR6 (DRB1*1301) gene. Springer-Verlag, 1996 Major histocompatibility complex (MHC) nationallicence HLA antigens nationallicence Takayasu arteritis nationallicence Girona Eduardo Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico aut Yamamoto-Furusho Jesús Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Vasco de Quiroga 15, 14000, Tlalpan, México, D.F., México aut Cutiño Teresa Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico aut Reyes Pedro Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico aut Vargas-Alarcón Gilberto Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Vasco de Quiroga 15, 14000, Tlalpan, México, D.F., México aut Granados Julio Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Vasco de Quiroga 15, 14000, Tlalpan, México, D.F., México aut Alarcón-Segovia Donato Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Vasco de Quiroga 15, 14000, Tlalpan, México, D.F., México aut Heart and Vessels Springer-Verlag 11/6(1996-11-01), 277-280 0910-8327 11:6<277 1996 11 380 https://doi.org/10.1007/BF01747186 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01747186 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Girona Eduardo Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico aut NATIONALLICENCE 700 1- Yamamoto-Furusho Jesús Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Vasco de Quiroga 15, 14000, Tlalpan, México, D.F., México aut NATIONALLICENCE 700 1- Cutiño Teresa Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico aut NATIONALLICENCE 700 1- Reyes Pedro Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico aut NATIONALLICENCE 700 1- Vargas-Alarcón Gilberto Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Vasco de Quiroga 15, 14000, Tlalpan, México, D.F., México aut NATIONALLICENCE 700 1- Granados Julio Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Vasco de Quiroga 15, 14000, Tlalpan, México, D.F., México aut NATIONALLICENCE 700 1- Alarcón-Segovia Donato Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Vasco de Quiroga 15, 14000, Tlalpan, México, D.F., México aut NATIONALLICENCE 773 0- Heart and Vessels Springer-Verlag 11/6(1996-11-01), 277-280 0910-8327 11:6<277 1996 11 380 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer