caa a22 4500 477112684 CHVBK 20180405111614.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF01747189 doi (NATIONALLICENCE)springer-10.1007/BF01747189 Improvement of left ventricular diastolic dysfunction in hypertensive patients 1 month after ACE inhibition therapy: Evaluation by ultrasonic automated boundary detection [Elektronische Daten] [N. Angomachalelis, A. Hourzamanis, S. Sideri, E. Serasli, Chr Vamvalis] Summary: The purpose of this study was to detect any improvement in left ventricular diastolic dysfunction in hypertensive patients 1 month after cilazapril therapy. Twenty-three patients, 5 men and 18 women (mean age, 53.52 ± 9.10 years), with mild or moderate hypertension (160 ± 13/98 ± 10mm Hg), and free of other cardiac or systemic diseases, were studied using ultrasonic automated boundary detection (ABD) and pulsed Doppler echocardiography, before and 1 month after a daily dose of 2.5 mg of cilazapril. The following new ABD diastolic indices were determined: the time rate of area change in early diastole (dA/dt)E, that in late diastole (dA/dt)A, and their ratio (dA/dt)E/(dA/dt)A, while Doppler transmitral flow measurements of left ventricular diastolic filling were also simultaneously recorded. The ABD results showed left ventricular diastolic dysfunction (LVDD) in 9 of 23 patients (39%) compared with the ABD values of 12 normal volunteers. Neither method revealed any significant difference before and after treatment in the patient group as a whole. However, in the group of 9 patients with diastolic dysfunction, the ABD ratio (dA/dt)E/(dA/dt)A was significantly improved after cilazapril therapy (1.20 ± 0.21 versus 1.41 ± 0.17;P < 0.05). We concluded that a large percentage (39%) of patients with mild or moderate hypertension had reduced diastolic performance of the left ventricle at a stage of the disease when systolic dysfunction and/or hypertrophy were not evident. Significant improvement of diastolic dysfunction in hypertensive patients could be detected by the proposed ABD new diastolic indices 1 month after cilazapril therapy. In conclusion, automatic boundary detection should be a useful non-invasive modality for the early diagnosis of left ventricular diastolic dysfunction, as well as early recognition of its improvement. Springer-Verlag, 1996 Hypertension nationallicence LV function nationallicence LV diastolic dysfunction nationallicence Angiotensin-converting enzyme (ACE) inhibition therapy nationallicence Automatic boundary detection nationallicence Acoustic quantification nationallicence Angomachalelis N. Department of Internal Medicine, "G. Papanikolaou” General Regional Hospital, Aristotle University School of Medicine, 19, 25th Martiou Avenue, 54645, Thessaloniki, Macedonia, Greece aut Hourzamanis A. Department of Internal Medicine, "G. Papanikolaou” General Regional Hospital, Aristotle University School of Medicine, 19, 25th Martiou Avenue, 54645, Thessaloniki, Macedonia, Greece aut Sideri S. Department of Internal Medicine, "G. Papanikolaou” General Regional Hospital, Aristotle University School of Medicine, 19, 25th Martiou Avenue, 54645, Thessaloniki, Macedonia, Greece aut Serasli E. Department of Internal Medicine, "G. Papanikolaou” General Regional Hospital, Aristotle University School of Medicine, 19, 25th Martiou Avenue, 54645, Thessaloniki, Macedonia, Greece aut Vamvalis Chr Department of Internal Medicine, "G. Papanikolaou” General Regional Hospital, Aristotle University School of Medicine, 19, 25th Martiou Avenue, 54645, Thessaloniki, Macedonia, Greece aut Heart and Vessels Springer-Verlag 11/6(1996-11-01), 303-309 0910-8327 11:6<303 1996 11 380 https://doi.org/10.1007/BF01747189 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01747189 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Angomachalelis N. Department of Internal Medicine, "G. Papanikolaou” General Regional Hospital, Aristotle University School of Medicine, 19, 25th Martiou Avenue, 54645, Thessaloniki, Macedonia, Greece aut NATIONALLICENCE 700 1- Hourzamanis A. Department of Internal Medicine, "G. Papanikolaou” General Regional Hospital, Aristotle University School of Medicine, 19, 25th Martiou Avenue, 54645, Thessaloniki, Macedonia, Greece aut NATIONALLICENCE 700 1- Sideri S. Department of Internal Medicine, "G. Papanikolaou” General Regional Hospital, Aristotle University School of Medicine, 19, 25th Martiou Avenue, 54645, Thessaloniki, Macedonia, Greece aut NATIONALLICENCE 700 1- Serasli E. Department of Internal Medicine, "G. Papanikolaou” General Regional Hospital, Aristotle University School of Medicine, 19, 25th Martiou Avenue, 54645, Thessaloniki, Macedonia, Greece aut NATIONALLICENCE 700 1- Vamvalis Chr Department of Internal Medicine, "G. Papanikolaou” General Regional Hospital, Aristotle University School of Medicine, 19, 25th Martiou Avenue, 54645, Thessaloniki, Macedonia, Greece aut NATIONALLICENCE 773 0- Heart and Vessels Springer-Verlag 11/6(1996-11-01), 303-309 0910-8327 11:6<303 1996 11 380 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer