caa a22 4500 477112714 CHVBK 20180405111614.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF01745170 doi (NATIONALLICENCE)springer-10.1007/BF01745170 Induction of thrombolysis and prevention of thrombus formation by local drug delivery with a double-occlusion balloon catheter [Elektronische Daten] [Takanobu Tomaru, Yoshiharu Fujimori, Fumitaka Nakamura, Naoto Aoki, Yoshimitsu Sakamoto, Kohichi Kawai, Masao Omata, Yasumi Uchida] Summary: The efficacy of the local delivery of an antithrombotic drug in preventing thrombosis and enabling thrombolysis was investigated in 29 dogs. An antithrombotic drug (heparin, 25U/kg), or an antithrombin (argatroban, 0.05 mg/kg) was infused into injured canine iliac arteries, using a double-occlusion balloon catheter, and the preventive effect of the drug was evaluated. Local delivery of low-dose tissuetype plasminogen activator (t-PA; Tisokinase, 50 000 U; Kowa, Nagoya and Asahi Chemical Industries, Fuji, Japan) into thrombosed canine iliac arteries, using the same catheter, or intravenous infusion of low-dose or high-dose t-PA (30 000U/kg), was also performed. Angiographically, stenotic thrombosis was 2% by local delivery of argatroban and 7% by local delivery of heparin (P < 0.01 vs each control; 47% and 51% respectively). Thrombotic stenosis, as observed by angiography, decreased from 91% to 9% after local delivery of t-PA, and from 94% to 52% in controls. Local delivery of t-PA effectively reduced the thrombus size (P < 0.01 vs control). After systemic intravenous delivery of low-dose t-PA, no reduction of residual thrombotic stenosis, was observed. Reduction of residual thrombotic stenosis after intravenous delivery of high-dose t-PA, was similar to that achieved by local delivery of the drug. Angioscopy demonstrated a similar trend. High-dose drug delivery reduced systemic coagulability. Local delivery of an antithrombotic drug, using a double-occlusion balloon catheter, effectively prevented thrombus formation, and local delivery of t-PA induced thrombolysis without exerting a significant influence on coagulability. Springer-Verlag, 1996 Tissue type plasminogen activator (t-PA) nationallicence Thrombolysis nationallicence Double occlusion balloon catheter nationallicence Local delivery nationallicence Tomaru Takanobu Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut Fujimori Yoshiharu Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut Nakamura Fumitaka Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut Aoki Naoto Tokyo Metropolitan Research Laboratory of Public Health, Division of Pathology, Tokyo, Japan aut Sakamoto Yoshimitsu Tokyo Metropolitan Research Laboratory of Public Health, Division of Pathology, Tokyo, Japan aut Kawai Kohichi Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut Omata Masao Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut Uchida Yasumi Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut Heart and Vessels Springer-Verlag 11/3(1996-05-01), 123-132 0910-8327 11:3<123 1996 11 380 https://doi.org/10.1007/BF01745170 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01745170 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tomaru Takanobu Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujimori Yoshiharu Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakamura Fumitaka Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut NATIONALLICENCE 700 1- Aoki Naoto Tokyo Metropolitan Research Laboratory of Public Health, Division of Pathology, Tokyo, Japan aut NATIONALLICENCE 700 1- Sakamoto Yoshimitsu Tokyo Metropolitan Research Laboratory of Public Health, Division of Pathology, Tokyo, Japan aut NATIONALLICENCE 700 1- Kawai Kohichi Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut NATIONALLICENCE 700 1- Omata Masao Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut NATIONALLICENCE 700 1- Uchida Yasumi Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer-Verlag 11/3(1996-05-01), 123-132 0910-8327 11:3<123 1996 11 380 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer