caa a22 4500 477112757 CHVBK 20180405111614.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF01745171 doi (NATIONALLICENCE)springer-10.1007/BF01745171 Local treatment with an antithrombotic drug reduces thrombus size in coronary and peripheral thrombosed arteries [Elektronische Daten] [Takanobu Tomaru, Fumitaka Nakamura, Naoto Aoki, Yoshimitsu Sakamoto, Masao Omata, Yasumi Uchida] Summary: Since the treatment of thrombotic disease by antithrombotic drugs may be associated with bleeding complications, a local delivery technique for administration of the drug may be useful. The efficacy of low-dose local delivery of an antithrombotic drug on thrombosis was investigated in 73 dogs. The antithrombotic drug (heparin, 25U/kg, antithrombin: argatroban, 0.05mg/kg, or defibrinogenating agent: batroxobin, 0.05U/kg) was infused locally to a 1-h-old thrombus, and no drug was given in controls. The effect of the local delivery on the thrombus was evaluated. Low- and high-dose systemic drug delivery was also evaluated. The mean reduction in thrombotic coronary stenosis observed by angiography was 30.3% with argatroban, 22% with heparin, and 20.8% with batroxobin (P < 0.005 vs controls). Systemic delivery of low-dose heparin or argatroban did not induce any change in thrombus size. With high-dose systemic drug delivery (heparin 250 U/kg, argatroban 0.5 mg/kg), the mean reduction of thrombotic stenosis was 15.2% with heparin and 32.8% with argatroban (P < 0.005 vs controls). In iliac arterial thrombosis, after local delivery of the drugs, the mean reduction of thrombotic stenosis observed by angiography was 24.4% in the argatroban group, and 19.2% in the heparin group (P < 0.05 vs controls, respectively). With high-dose systemic heparin delivery, the mean reduction of the thrombotic stenosis was 13.2% (P < 0.01 vs control). Angioscopy also demonstrated a similar trend. The high-dose drug delivery reduced systemic coagulability. Thus, local delivery of an antithrombotic agent can reduce the thrombus size in the coronary and iliac arteries without having any significant influence on coagulability. Springer-Verlag, 1996 Local delivery nationallicence Coronary thrombosis nationallicence Antithrombin nationallicence Defibrinogenating agent nationallicence Angioscopy nationallicence Tomaru Takanobu Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut Nakamura Fumitaka Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut Aoki Naoto Tokyo Metropolitan Research Laboratory of Public Health, Division of Pathology, Tokyo, Japan aut Sakamoto Yoshimitsu Tokyo Metropolitan Research Laboratory of Public Health, Division of Pathology, Tokyo, Japan aut Omata Masao Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut Uchida Yasumi Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut Heart and Vessels Springer-Verlag 11/3(1996-05-01), 133-144 0910-8327 11:3<133 1996 11 380 https://doi.org/10.1007/BF01745171 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01745171 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tomaru Takanobu Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakamura Fumitaka Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut NATIONALLICENCE 700 1- Aoki Naoto Tokyo Metropolitan Research Laboratory of Public Health, Division of Pathology, Tokyo, Japan aut NATIONALLICENCE 700 1- Sakamoto Yoshimitsu Tokyo Metropolitan Research Laboratory of Public Health, Division of Pathology, Tokyo, Japan aut NATIONALLICENCE 700 1- Omata Masao Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut NATIONALLICENCE 700 1- Uchida Yasumi Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer-Verlag 11/3(1996-05-01), 133-144 0910-8327 11:3<133 1996 11 380 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer