caa a22 4500 477112765 CHVBK 20180405111614.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF01745169 doi (NATIONALLICENCE)springer-10.1007/BF01745169 Expression of vascular endothelial growth factor in human myocardial infarction [Elektronische Daten] [Kaoru Shinohara, Toshiya Shinohara, Naoki Mochizuki, Yuka Mochizuki, Hirofumi Sawa, Tetsuro Kohya, Miri Fujita, Yasunori Fujioka, Akira Kitabatake, Kazuo Nagashima] Summary: To define mechanisms that may influence collateral circulation and angiogenesis, we investigated vascular endothelial growth factor (VEGF) mRNA expression in human hearts. In non-ischemic human hearts, VEGF mRNA was not detected in vessels, but was found in cardiomyocytes. In hearts with myocardial infarction, the intensity of the VEGF signal was much higher in smooth muscle cells of arterioles adjacent to necrosis and in infiltrating macrophages than in myocytes around the site of the necrosis. This study suggests that levels of VEGF expression are high in smooth muscle cells and macrophages around infarcted areas after myocardial infarction and that VEGF may play a role in promoting collateral circulation and angiogenesis in human ischemic hearts. Springer-Verlag, 1996 vascular endothelial growth factor (VEGF) nationallicence Acute myocardial infarction nationallicence Human heart nationallicence in situ hybridization nationallicence Shinohara Kaoru Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut Shinohara Toshiya Department of Pathology, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut Mochizuki Naoki Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut Mochizuki Yuka Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut Sawa Hirofumi Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut Kohya Tetsuro Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut Fujita Miri Department of Pathology, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut Fujioka Yasunori Department of Pathology, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut Kitabatake Akira Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut Nagashima Kazuo Department of Pathology, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut Heart and Vessels Springer-Verlag 11/3(1996-05-01), 113-122 0910-8327 11:3<113 1996 11 380 https://doi.org/10.1007/BF01745169 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01745169 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shinohara Kaoru Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Shinohara Toshiya Department of Pathology, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Mochizuki Naoki Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Mochizuki Yuka Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Sawa Hirofumi Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Kohya Tetsuro Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Fujita Miri Department of Pathology, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Fujioka Yasunori Department of Pathology, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Kitabatake Akira Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Nagashima Kazuo Department of Pathology, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer-Verlag 11/3(1996-05-01), 113-122 0910-8327 11:3<113 1996 11 380 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer