caa a22 4500 477112803 CHVBK 20180405111614.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF02559996 doi (NATIONALLICENCE)springer-10.1007/BF02559996 Elevated circulating levels of tumor necrosis factor in patients with mitral valve disease and ventricular septum defect [Elektronische Daten] [Yukihito Sato, Yoshiki Takatsu, Haruyasu Ito, Kazuaki Kataoka, Yuzou Takeuchi, Akira Matsumori] Summary: Elevated levels of circulating tumor necrosis factor (TNF)-α have been reported in patients with decreased left ventricular ejection fraction. Also, TNF has been reported to depress myocardial contractility. In our previous study, no correlation was found between the plasma level of TNF and clinical parameters in patients with cardiomyopathy. In the present study, we detected elevated levels of circulating TNF-α in 5 out of 15 patients with mitral valve disease and in 1 patient with ventricular septal defect whose left ventricular ejection fraction was within the normal range. The levels of TNF-α were not correlated with any hemodynamic parameters. Further studies are necessary to clarify the mechanisms of the regulation and effects of TNF-α in patients with chronic heart failure. Springer-Verlag, 1996 Tumor necrosis factor nationallicence Cytokine nationallicence Heart failure nationallicence Mitral valve disease nationallicence Sato Yukihito Division of Cardiology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashidaimotsucho, Amagasaki, 660, Hyogo, Japan aut Takatsu Yoshiki Division of Cardiology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashidaimotsucho, Amagasaki, 660, Hyogo, Japan aut Ito Haruyasu Division of Cardiology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashidaimotsucho, Amagasaki, 660, Hyogo, Japan aut Kataoka Kazuaki Division of Cardiology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashidaimotsucho, Amagasaki, 660, Hyogo, Japan aut Takeuchi Yuzou Division of Cardiology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashidaimotsucho, Amagasaki, 660, Hyogo, Japan aut Matsumori Akira Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaracho Shogoin, Sakyoku, 606, Kyoto, Japan aut Heart and Vessels Springer-Verlag 11/4(1996-07-01), 218-220 0910-8327 11:4<218 1996 11 380 https://doi.org/10.1007/BF02559996 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02559996 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sato Yukihito Division of Cardiology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashidaimotsucho, Amagasaki, 660, Hyogo, Japan aut NATIONALLICENCE 700 1- Takatsu Yoshiki Division of Cardiology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashidaimotsucho, Amagasaki, 660, Hyogo, Japan aut NATIONALLICENCE 700 1- Ito Haruyasu Division of Cardiology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashidaimotsucho, Amagasaki, 660, Hyogo, Japan aut NATIONALLICENCE 700 1- Kataoka Kazuaki Division of Cardiology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashidaimotsucho, Amagasaki, 660, Hyogo, Japan aut NATIONALLICENCE 700 1- Takeuchi Yuzou Division of Cardiology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashidaimotsucho, Amagasaki, 660, Hyogo, Japan aut NATIONALLICENCE 700 1- Matsumori Akira Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaracho Shogoin, Sakyoku, 606, Kyoto, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer-Verlag 11/4(1996-07-01), 218-220 0910-8327 11:4<218 1996 11 380 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer