caa a22 4500 477112854 CHVBK 20180405111614.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF02559990 doi (NATIONALLICENCE)springer-10.1007/BF02559990 Flow patterns in dog aortic arch under a steady flow condition simulating mid-systole [Elektronische Daten] [Shunsuke Endo, Yasunori Sohara, Takeshi Karino] Summary: To elucidate the possible connection between blood flow and localized pathogenesis and the development of atherosclerosis in humans, we studied the flow patterns and the distribution of fluid axial velocity and wall shear stress in the aortic arch in detail. This was done by means of flow visualization and highspeed cinemicrographic techniques, using transparent aortic trees prepared from the dog. Under a steady flow condition at inflow Reynolds numbers of 700-1600, which simulated physiologic conditions at early- to midsystole, slow, spiral secondary, and recirculation flows formed along the left anterior wall of the aortic arch and at the entrance of each side branch adjacent to the vessel wall opposite the flow divider, respectively. The flow in the aortic arch consisted of three major components, namely, an undisturbed parallel flow located close to the common median plane of the arched aorta and its side branches, a clockwise rotational flow formed along the left ventral wall, and the main flow to the side branches, located along the right dorsal wall of the ascending aorta. Thus, looking down the aorta from its origin, the flow in the aortic arch appeared as a single helical flow revolving in a clockwise direction. Regions of low wall shear stress were located along the leading edge of each side branch opposite the flow divider where slow recirculation flow formed, and along the left ventral wall where slow spiral secondary flows formed. If we assume that the flow patterns in the human aortic arch well resemble those observed in the dog, then it is likely that atherosclerotic lesions develop preferentially at these sites of low wall shear stress in the same manner as in human coronary and cerebral arteries. Springer-Verlag, 1996 Aortic arch nationallicence Atherosclerosis nationallicence Flow patterns nationallicence Flow disturbance nationallicence Wall shear stress nationallicence Endo Shunsuke Department of Thoracic and Cardiovascular Surgery, Jichi Medical School, Tochigi, Japan aut Sohara Yasunori Department of Thoracic and Cardiovascular Surgery, Jichi Medical School, Tochigi, Japan aut Karino Takeshi Research Institute for Electronic Science, Hokkaido University, North 12 West 6, North District, 060, Sapporo, Hokkaido, Japan aut Heart and Vessels Springer-Verlag 11/4(1996-07-01), 180-191 0910-8327 11:4<180 1996 11 380 https://doi.org/10.1007/BF02559990 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02559990 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Endo Shunsuke Department of Thoracic and Cardiovascular Surgery, Jichi Medical School, Tochigi, Japan aut NATIONALLICENCE 700 1- Sohara Yasunori Department of Thoracic and Cardiovascular Surgery, Jichi Medical School, Tochigi, Japan aut NATIONALLICENCE 700 1- Karino Takeshi Research Institute for Electronic Science, Hokkaido University, North 12 West 6, North District, 060, Sapporo, Hokkaido, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer-Verlag 11/4(1996-07-01), 180-191 0910-8327 11:4<180 1996 11 380 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer