caa a22 4500 477112870 CHVBK 20180405111614.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF02559991 doi (NATIONALLICENCE)springer-10.1007/BF02559991 KATP channel opening does not contribute significantly to the vasodilatory effect of SH-group-containing ACE inhibitors [Elektronische Daten] [H. Köppel, S. Holzmann, W. Klein, E. Horn, S. Horn, R. Gasser] Summary: Angiotensin-converting enzyme (ACE) inhibitors are widely used in the management of hypertension, heart failure, and nephropathy. It has been suggested that ACE inhibitors containing the sulfhydryl group (SH) have an additional effect on KATP channels. To prove this hypothesis, we studied the effects of the SH-containing ACE inhibitors, captopril and zofenopril, on KATP channel opening of bovine coronary arteries and guinea pig thoracic aortas. Bovine coronary arteries were precontracted with the thromboxane A2 analogue, U46619, and guinea pig thoracic aortas were precontracted with phenylephrine and then relaxed with either captopril or zofenopril (n=8). Inhibition of KATP channel opening with glibenclamide moderately attenuated the zofenopril-induced relaxation of guinea pig thoracic aorta. However, in the bovine coronary arteries, the relaxing effect of both captopril and zofenopril remained uneffected by glibenclamide. In experiments with enalapril (a non SH-containing ACE inhibitor:n=6) on guinea pig thoracic aortas, no effect on KATP channels could be seen. From our experiments, we conclude that the postulated opening of KATP channels by SH-group-containing ACE inhibitors contributes little to the vasodilation of guinea pig thoracic aortas caused by ACE inhibitors, and that SH groups have no influence upon KATP channels of bovine coronary arteries. Springer-Verlag, 1996 KATP channel nationallicence ACE inhibitor nationallicence Coronary nationallicence Smooth muscle nationallicence Köppel H. Experimental Cardiology, Department of Internal Medicine, University of Graz, Auenbruggerplatz 15, A-8036, Graz, Austria aut Holzmann S. Instite of Pharmacology and Toxicology, University of Graz, Auenbruggerplatz 15, A-8036, Graz, Austria aut Klein W. Experimental Cardiology, Department of Internal Medicine, University of Graz, Auenbruggerplatz 15, A-8036, Graz, Austria aut Horn E. Experimental Cardiology, Department of Internal Medicine, University of Graz, Auenbruggerplatz 15, A-8036, Graz, Austria aut Horn S. Experimental Cardiology, Department of Internal Medicine, University of Graz, Auenbruggerplatz 15, A-8036, Graz, Austria aut Gasser R. Experimental Cardiology, Department of Internal Medicine, University of Graz, Auenbruggerplatz 15, A-8036, Graz, Austria aut Heart and Vessels Springer-Verlag 11/4(1996-07-01), 192-196 0910-8327 11:4<192 1996 11 380 https://doi.org/10.1007/BF02559991 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02559991 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Köppel H. Experimental Cardiology, Department of Internal Medicine, University of Graz, Auenbruggerplatz 15, A-8036, Graz, Austria aut NATIONALLICENCE 700 1- Holzmann S. Instite of Pharmacology and Toxicology, University of Graz, Auenbruggerplatz 15, A-8036, Graz, Austria aut NATIONALLICENCE 700 1- Klein W. Experimental Cardiology, Department of Internal Medicine, University of Graz, Auenbruggerplatz 15, A-8036, Graz, Austria aut NATIONALLICENCE 700 1- Horn E. Experimental Cardiology, Department of Internal Medicine, University of Graz, Auenbruggerplatz 15, A-8036, Graz, Austria aut NATIONALLICENCE 700 1- Horn S. Experimental Cardiology, Department of Internal Medicine, University of Graz, Auenbruggerplatz 15, A-8036, Graz, Austria aut NATIONALLICENCE 700 1- Gasser R. Experimental Cardiology, Department of Internal Medicine, University of Graz, Auenbruggerplatz 15, A-8036, Graz, Austria aut NATIONALLICENCE 773 0- Heart and Vessels Springer-Verlag 11/4(1996-07-01), 192-196 0910-8327 11:4<192 1996 11 380 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer