caa a22 4500 477112935 CHVBK 20180405111614.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF01746206 doi (NATIONALLICENCE)springer-10.1007/BF01746206 Is the Presence of Hyperlipidemia Associated with Impairment of Endothelium-Dependent Neointimal Relaxation After Percutaneous Transluminal Coronary Angioplasty? [Elektronische Daten] [Akihiko Sakai, Atsushi Hirayama, Takayoshi Adachi, Shinsuke Nanto, Masatsugu Hori, Michitoshi Inoue, Takenobu Kamada, Kazuhisa Kodama] Summary: To determine whether hyperlipidemia affects the endothelium-dependent vasomotor response along the dilated vessel after percutaneous transluminal coronary angioplasty (PTCA), we evaluated 32 patients with one-vessel disease, 3-6 months after successful PTCA without restenosis. Fourteen patients had mild stenotic lesions not subjected to PTCA (non-PTCA sites) in addition to the PTCA sites. Vessel diameter changes at 32 PTCA and 36 non-PTCA sites were assessed by quantitative angiography, before and after intracoronary injection of acetylcholine (20µg to the right and 50µg to the left coronary artery) and of nitroglycerin (0.1-0.3mg). The acetylcholine response ranged from 46% (dilation) to −100% (constriction). All coronary arteries were dilated in response to nitroglycerin, which suggested preservation of the function of vascular smooth muscle, and the presence of an abnormality in endothelial function in those patients with a constrictor response to acetylcholine. There was a negative correlation between the acetylcholine response and the serum total cholesterol level at PTCA sites (r = −0.37;P = 0.038) and at non-PTCA sites (r = −0.46;P = 0.005). These findings indicate that hyperlipidemia is associated with a loss of endothelium-dependent vasodilation, not only at non-PTCA but also at PTCA sites, at which restoration of endothelial function might have occurred. They also suggest that hyperlipidemia may be related to the functional state of the regenerated endothelium at sites where PTCA had been previously performed. Springer-Verlag, 1996 Endothelium-dependent vasomotor response nationallicence Hyperlipidemia nationallicence PTCA nationallicence Sakai Akihiko Cardiovascular Division, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, 543, Osaka, Japan aut Hirayama Atsushi Cardiovascular Division, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, 543, Osaka, Japan aut Adachi Takayoshi Cardiovascular Division, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, 543, Osaka, Japan aut Nanto Shinsuke Cardiovascular Division, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, 543, Osaka, Japan aut Hori Masatsugu First Department of Medicine, Osaka University School of Medicine, 2-2 Yamadaoka, Suita-city, 565, Osaka, Japan aut Inoue Michitoshi Department of Medical Information Science, Osaka University Hospital, 2-15 Yamadaoka, Suita-city, 565, Osaka, Japan aut Kamada Takenobu First Department of Medicine, Osaka University School of Medicine, 2-2 Yamadaoka, Suita-city, 565, Osaka, Japan aut Kodama Kazuhisa Cardiovascular Division, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, 543, Osaka, Japan aut Heart and Vessels Springer-Verlag 11/5(1996-09-01), 255-261 0910-8327 11:5<255 1996 11 380 https://doi.org/10.1007/BF01746206 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01746206 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sakai Akihiko Cardiovascular Division, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, 543, Osaka, Japan aut NATIONALLICENCE 700 1- Hirayama Atsushi Cardiovascular Division, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, 543, Osaka, Japan aut NATIONALLICENCE 700 1- Adachi Takayoshi Cardiovascular Division, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, 543, Osaka, Japan aut NATIONALLICENCE 700 1- Nanto Shinsuke Cardiovascular Division, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, 543, Osaka, Japan aut NATIONALLICENCE 700 1- Hori Masatsugu First Department of Medicine, Osaka University School of Medicine, 2-2 Yamadaoka, Suita-city, 565, Osaka, Japan aut NATIONALLICENCE 700 1- Inoue Michitoshi Department of Medical Information Science, Osaka University Hospital, 2-15 Yamadaoka, Suita-city, 565, Osaka, Japan aut NATIONALLICENCE 700 1- Kamada Takenobu First Department of Medicine, Osaka University School of Medicine, 2-2 Yamadaoka, Suita-city, 565, Osaka, Japan aut NATIONALLICENCE 700 1- Kodama Kazuhisa Cardiovascular Division, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, 543, Osaka, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer-Verlag 11/5(1996-09-01), 255-261 0910-8327 11:5<255 1996 11 380 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer