caa a22 4500 477112951 CHVBK 20180405111614.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF01746204 doi (NATIONALLICENCE)springer-10.1007/BF01746204 Enhancement of coronary reactive hyperemia in patients with ischemic myocardial tolerance during angioplasty [Elektronische Daten] [Takahiro Tanaka, Hiroshi Nonogi, Shunichi Miyazaki, Yoichi Goto, Akira Itoh, Satoshi Daikoku, Yusuke Yamamoto] Summary: The purpose of this study was to elucidate the effect of repeated brief coronary occlusions on reactive hyperemia during percutaneous transluminal coronary angioplasty (PTCA) in patients with or without ischemic tolerance. Seventeen patients undergoing PTCA for chronic stable angina were studied. Patients with well developed collateral vessels were excluded. After successful predilatation, coronary flow velocity was recorded with the use of a Doppler flow guide wire, and reactive hyperemia was assessed immediately after each of two 2-min coronary occlusions followed by 2 mins of reperfusion. The intracoronary electrocardiogram (icECG) was recorded via the flow guide wire placed in the center of the ischemic zone. Patients were divided into two groups: those who showed a reduction of ST elevation in the icECG recorded at the time of the second coronary occlusion (group I), and those who showed no difference in ST elevation between the two occlusions (group II). There were no significant differences in blood pressure, heart rate, or baseline coronary flow velocity between the two groups before the first occlusion, but the ST elevation at the time of the first coronary occlusion was greater in group I than in group II (8.9 ± 6.2 versus 1.1 ± 2.0mm,P < 0.01). Reactive hyperemia was significantly greater after the second coronary occlusion than after the first in group I (22.1 ± 15.8 versus 30.4 ± 21.0cm/s,P < 0.05), but it did not change in group II (25.6 ± 13.0 versus 23.5 ± 11.2cm/s NS). Reactive hyperemia was enhanced in patients with ischemic tolerance who showed a reduction in ST elevation in the icECG. These results suggest that observed reactive hyperemia does not necessarily reflect the severity of ischemia. Springer-Verlag, 1996 Reactive hyperemia nationallicence Angioplasty nationallicence Ischemia nationallicence Preconditioning nationallicence Tanaka Takahiro Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut Nonogi Hiroshi Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut Miyazaki Shunichi Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut Goto Yoichi Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut Itoh Akira Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut Daikoku Satoshi Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut Yamamoto Yusuke Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut Heart and Vessels Springer-Verlag 11/5(1996-09-01), 242-247 0910-8327 11:5<242 1996 11 380 https://doi.org/10.1007/BF01746204 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01746204 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tanaka Takahiro Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Nonogi Hiroshi Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Miyazaki Shunichi Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Goto Yoichi Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Itoh Akira Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Daikoku Satoshi Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Yamamoto Yusuke Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer-Verlag 11/5(1996-09-01), 242-247 0910-8327 11:5<242 1996 11 380 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer