caa a22 4500 477113028 CHVBK 20180405111615.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF01744505 doi (NATIONALLICENCE)springer-10.1007/BF01744505 Pravastatin affects blood pressure and vascular reactivity [Elektronische Daten] [Nanfang Li, Makoto Sawamura, Yasuo Nara, Katsumi Ikeda, Yukio Yamori] Summary: To investigate the effect of endogenous cholesterol synthesis on blood pressure and vascular response, a HMG CoA reductase inhibitor, pravastatin (1 or 10mg/kg per day) was administered orally for 2 or 4 weeks to spontaneously hypertensive rats (SHR/lzm) and normotensive Wistar-Kyoto (WKY/lzm) rats. Blood pressure was significantly increased in the pravastatin-treated groups of both strains, occurring in WKY after a longer treatment period than in SHR. The thoracic aortas from SHR and WKY were pretreated with pravastatin (10−4M). The vascular response to norepinephrine in terms of both contractility and sensitivity, was increased in the pravastatin-treated SHR aorta but not in the WKY aorta. The increased response was not observed in the presence of mevalonate. Acetylcholine-induced vascular relaxation in the aortas from both strains was not affected by pravastatin pretreatment. These results suggest that the vascular response to norepinephrine may be affected by the intracellular cholesterol synthesis pathway. Springer-Verlag, 1996 Blood pressure nationallicence Mevalonate nationallicence Pravastatin nationallicence Spontaneously hypertensive rats nationallicence Vasocontraction nationallicence Li Nanfang Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, 606, Kyoto, Japan aut Sawamura Makoto Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, 606, Kyoto, Japan aut Nara Yasuo Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, 606, Kyoto, Japan aut Ikeda Katsumi Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, 606, Kyoto, Japan aut Yamori Yukio Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, 606, Kyoto, Japan aut Heart and Vessels Springer-Verlag 11/2(1996-03-01), 64-68 0910-8327 11:2<64 1996 11 380 https://doi.org/10.1007/BF01744505 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01744505 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Nanfang Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Sawamura Makoto Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Nara Yasuo Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Ikeda Katsumi Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Yamori Yukio Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer-Verlag 11/2(1996-03-01), 64-68 0910-8327 11:2<64 1996 11 380 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer