caa a22 4500 477113052 CHVBK 20180405111615.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF01744509 doi (NATIONALLICENCE)springer-10.1007/BF01744509 Antiischemic effect of intracoronary diltiazem on myocardial ischemia during PTCA [Elektronische Daten] [Katsumi Saito, Hiroshi Nonogi, Yoichi Goto, Akira Itoh, Satoshi Daikoku, Shunichi Miyazaki, Kazuo Haze] Summary: To evaluate the effect of intracoronary diltiazem on myocardial ischemia during percutaneous transluminal coronary angioplasty (PTCA), 38 patients were randomly assigned to receive inactive placebo (n = 19; group C) or a low dose (1 mg,n = 10; group D1), or a high dose (2 or 3mg,n = 9; group D2) of diltiazem in a double-blind manner. The agent was administered directly into the coronary artery via a balloon catheter following a control balloon inflation. Chest pain score (maximum, 10) and the magnitude of ischemic ST elevation on standard and intracoronary electrocardiograms (ECGs) during a balloon inflation were assessed in the control and posttreatment periods. After the administration of diltiazem, the chest pain score was significantly decreased in group D1 (control: 5.1 ± 3.6, posttreatment: 3.8 ± 3.1,P < 0.01) and group D2 (3.4 ± 2.5 vs 2.5 ± 2.0,P < 0.01), but not in group C (4.1 ± 3.1 vs 3.7 ± 3.3, difference not significant). The magnitude of ST elevation relative to the control on standard and intracoronary ECGs was significantly smaller in groups D1 and D2 than in group C (standard ECG; D1: 51.8 ± 10.6% of control, D2: 41.6 ± 28.7% vs C: 93.3 ± 15.6% and intracoronary ECG; D1: 47.1 ± 11.7% of control, D2: 27.5 ± 26.9% vs C: 94.6 ± 29.3%, allP < 0.01). Although systolic blood pressure decreased slightly in groups D1 and D2, there was no significant correlation between the change in ST elevation and the change in the rate-pressure product. Pretreatment with a small dose of intracoronary diltiazem attenuated myocardial ischemia during PTCA and this pretreatment may enable us to perform balloon inflation for a longer period. Springer-Verlag, 1996 Diltiazem nationallicence PTCA nationallicence Intracoronary ECG nationallicence Myocardial ischemia nationallicence Myocardial protection nationallicence Saito Katsumi Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut Nonogi Hiroshi Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut Goto Yoichi Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut Itoh Akira Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut Daikoku Satoshi Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut Miyazaki Shunichi Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut Haze Kazuo Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut Heart and Vessels Springer-Verlag 11/2(1996-03-01), 92-99 0910-8327 11:2<92 1996 11 380 https://doi.org/10.1007/BF01744509 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01744509 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Saito Katsumi Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Nonogi Hiroshi Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Goto Yoichi Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Itoh Akira Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Daikoku Satoshi Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Miyazaki Shunichi Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Haze Kazuo Division of Cardiology, National Cardiovascular Center, 5-7-1 Fujishirodai, 565, Suita, Osaka, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer-Verlag 11/2(1996-03-01), 92-99 0910-8327 11:2<92 1996 11 380 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer