caa a22 4500 477113915 CHVBK 20180405111617.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF00451109 doi (NATIONALLICENCE)springer-10.1007/BF00451109 Lisinopril has no natriuretic effect in elderly: A study of the single-dose response in aged vs young individuals [Elektronische Daten] [Dominique Chevet, Jean-Pierre Mallie, Claude Jeandel] In order to evaluate the short-term effect of angio-converting-enzyme (ACE) inhibition on the renal water and electrolyte handling in healthy elderly, we compared the actions of a single oral dose of lisinopril (Prinivil, 20 mg) in 13 healthy individuals over 75 years of age (82.6 ± 5.8 yrs) with that of 6 healthy young subjects (26.2 ± 0.7 yrs). No variations in serum sodium were observed in either groups. In the young group, we observed an increase in sodium excretion and glomerular filtration rates (creatinine clearance). In the aged group, we did not find any increase in sodium excretion and GFR remained unchanged, while diuresis decreased. The possible mechanisms for this discrepancy are discussed. The aged kidney submitted to ACE inhibition reacts in a different way than the younger kidney and this could lead, at least theoretically, to sodium retention. The therapeutic use of ACE inhibitors should be carefully monitored when a natriuretic effect is required. Kluwer Academic Publishers, 1996 aging nationallicence angiotensin-converting-enzyme inhibition nationallicence effective water clearance nationallicence lisinopril nationallicence natriuresis nationallicence renal function nationallicence Chevet Dominique Nephrologie, C.H.U., Dijon aut Mallie Jean-Pierre Exploration Fonctionnelle Rénale, C.H.U., Nancy aut Jeandel Claude Medecine Interne, C.H.U. Nancy, France aut Geriatric Nephrology and Urology Kluwer Academic Publishers 6/2(1996-01-01), 69-74 0924-8455 6:2<69 1996 6 10715 https://doi.org/10.1007/BF00451109 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00451109 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chevet Dominique Nephrologie, C.H.U., Dijon aut NATIONALLICENCE 700 1- Mallie Jean-Pierre Exploration Fonctionnelle Rénale, C.H.U., Nancy aut NATIONALLICENCE 700 1- Jeandel Claude Medecine Interne, C.H.U. Nancy, France aut NATIONALLICENCE 773 0- Geriatric Nephrology and Urology Kluwer Academic Publishers 6/2(1996-01-01), 69-74 0924-8455 6:2<69 1996 6 10715 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer