caa a22 4500 477113923 CHVBK 20180405111617.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF00451114 doi (NATIONALLICENCE)springer-10.1007/BF00451114 Primary glomerular diseases in the elderly Glomerulonephritis in the elderly [Elektronische Daten] [Claudio Ponticelli, Patrizia Passerini, Donata Cresseri] Recent studies have pointed out that the incidence of primary glomerular diseases is similar in the elderly and in younger populations. However the clinical characteristics of the different subtypes may be different in the advanced age. Minimal change nephropathy responds favorably to corticosteroids and/or cyclophosphamide, but many untreated or non-responder patients progress to end-stage renal disease or die from nephrotic complications. Focal and segmental glomerulosclerosis also has a severe prognosis in older patients but some 50% of patients may attain remission of the nephrotic syndrome with a prolonged corticosteroid treatment. The responders tend to maintain normal renal function over time. Membranoproliferative glomerulonephritis and IgA nephritis have a severe prognosis and do not respond to treatment. The clinical presentation and the outcome of membranous nephropathy are similar in the elderly and in younger adults. Corticosteroids are of little benefit while a 6-month treatment with chlorambucil and methylprednisolone may obtain remission of the nephrotic syndrome in about 2/3 of older patients. Crescentic glomerulonephritis has an ominous prognosis in older patients but some patients may improve if treatment with methylprednisolone pulses is started early. Acute postinfectious glomerulonephritis is often associated with renal failure in older patients. The prognosis may be severe. Kluwer Academic Publishers, 1996 elderly nationallicence glomerulonephritis nationallicence nephrotic syndrome nationallicence renal failure nationallicence Ponticelli Claudio Divisione di Nefrologia e Dialisi, IRCCS Ospedale Maggiore di Milano, Italy aut Passerini Patrizia Divisione di Nefrologia e Dialisi, IRCCS Ospedale Maggiore di Milano, Italy aut Cresseri Donata Divisione di Nefrologia e Dialisi, IRCCS Ospedale Maggiore di Milano, Italy aut Geriatric Nephrology and Urology Kluwer Academic Publishers 6/2(1996-01-01), 105-112 0924-8455 6:2<105 1996 6 10715 https://doi.org/10.1007/BF00451114 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00451114 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ponticelli Claudio Divisione di Nefrologia e Dialisi, IRCCS Ospedale Maggiore di Milano, Italy aut NATIONALLICENCE 700 1- Passerini Patrizia Divisione di Nefrologia e Dialisi, IRCCS Ospedale Maggiore di Milano, Italy aut NATIONALLICENCE 700 1- Cresseri Donata Divisione di Nefrologia e Dialisi, IRCCS Ospedale Maggiore di Milano, Italy aut NATIONALLICENCE 773 0- Geriatric Nephrology and Urology Kluwer Academic Publishers 6/2(1996-01-01), 105-112 0924-8455 6:2<105 1996 6 10715 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer