caa a22 4500 477117295 CHVBK 20180405111626.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF01875588 doi (NATIONALLICENCE)springer-10.1007/BF01875588 Lipid-stimulated somatostatin secretion in rainbow trout, Oncorhynchus mykiss [Elektronische Daten] [Nancy Carneiro, Carmen Eilertson, Mark Sheridan] Previous work has shown that somatostatins (SS) affect teleost lipid metabolism indirectly by inhibition of insulin (INS) and directly by stimulation of hepatic lipolysis. In the present study, rainbow trout (Oncorhynchus mykiss) were used to characterize further the lipid-SS relationship by evaluating how lipid, contributes to SS secretion bothin vivo andin vitro. In vivo hyperlipidemia was induced for up to 3 h by short-term (2 min) infusion of a triacylglycerol (TG)-rich lipid emulsion (20% Intralipid®). Plasma total lipid concentration increased 118 and 155% over control levels 1 h and 3 h, respectively, after infusion; much of this increase was due to elevated plasma fatty acids (FA), which increased 39 and 520%, respectively, over the same time-frame. The hyperlipidemic pattern was attended by a significant increase in the plasma concentration of SS. The specific effects of fatty acids were evaluated on isolated Brockmann bodies. Palmitic acid and oleic acid stimulated SS release 378 and 82%, respectively, over baseline levels. These results indicate that lipids, and in particular fatty acids, modulate SS secretion in rainbow trout. Kugler Publication, 1996 hyperlipidemia nationallicence fatty acids nationallicence somatostatin nationallicence rainbow trout nationallicence Oncorhynchus mykiss nationallicence Carneiro Nancy Department of Zoology, North Dakota State University, 58105, Fargo, ND, USA aut Eilertson Carmen Department of Zoology, North Dakota State University, 58105, Fargo, ND, USA aut Sheridan Mark Department of Zoology, North Dakota State University, 58105, Fargo, ND, USA aut Fish Physiology and Biochemistry Kluwer Academic Publishers 15/5(1996-11-01), 447-452 0920-1742 15:5<447 1996 15 10695 https://doi.org/10.1007/BF01875588 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01875588 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carneiro Nancy Department of Zoology, North Dakota State University, 58105, Fargo, ND, USA aut NATIONALLICENCE 700 1- Eilertson Carmen Department of Zoology, North Dakota State University, 58105, Fargo, ND, USA aut NATIONALLICENCE 700 1- Sheridan Mark Department of Zoology, North Dakota State University, 58105, Fargo, ND, USA aut NATIONALLICENCE 773 0- Fish Physiology and Biochemistry Kluwer Academic Publishers 15/5(1996-11-01), 447-452 0920-1742 15:5<447 1996 15 10695 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer