caa a22 4500 477117538 CHVBK 20180405111626.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF02437904 doi (NATIONALLICENCE)springer-10.1007/BF02437904 Effects of yohimbine on sexual experiences and nocturnal penile tumescence and rigidity in erectile dysfunction [Elektronische Daten] [Klaus Mann, Thomas Klingler, Susanne Noe, Joachim Röschke, Stefan Müller, Otto Benkert] The therapeutic effect of the α2-antagonist yohimbine in erectile dysfunction was studied in a double-blind placebo-controlled design. Thirty-one male patients underwent extensive clinical, urological, and psychiatric diagnosis and were dichotomically classified into an organic and a nonorganic subgroup. Following a 1-week placebo run-in period, patients were randomly assigned to a placebo or a verum group (yohimbine 15 mg daily) for a treatment period of 7 weeks. The Clinical Global Impression (CGI) scale was used as the primary efficacy parameter. Additionally, nocturnal penile tumescence and rigidity (NPTR) were measured. Global assessment of erectile function applying the CGI scale revealed, beyond a placebo effect in both organic and nonorganic patients, a therapeutic effect in the subgroup of nonorganic patients, with a significantly greater improvement in the yohimbine group compared to the placebo group. No superiority of yohimbine compared to placebo was found in the organic patients. These findings on the subjective level had no correlate in the NPTR recordings. The NPTR parameters were unchanged under yohimbine treatment in both the nonorganic and organic subgroup. No interrelation was found between subjective improvement and NPTR alterations. Polysomnographic control of the NPTR registrations ensured that the duration of REM sleep under treatment was not influenced. Plenum Publishing Corporation, 1996 yohimbine nationallicence erectile dysfunction nationallicence clinical global impression nationallicence nocturnal penile tumescence and rigidity nationallicence sleep EEG nationallicence Mann Klaus Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D-55101, Mainz, Germany aut Klingler Thomas Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D-55101, Mainz, Germany aut Noe Susanne Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D-55101, Mainz, Germany aut Röschke Joachim Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D-55101, Mainz, Germany aut Müller Stefan Department of Urology, University of Mainz, D-55101, Mainz, Germany aut Benkert Otto Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D-55101, Mainz, Germany aut Archives of Sexual Behavior Kluwer Academic Publishers-Plenum Publishers 25/1(1996-02-01), 1-16 0004-0002 25:1<1 1996 25 10508 https://doi.org/10.1007/BF02437904 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02437904 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mann Klaus Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D-55101, Mainz, Germany aut NATIONALLICENCE 700 1- Klingler Thomas Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D-55101, Mainz, Germany aut NATIONALLICENCE 700 1- Noe Susanne Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D-55101, Mainz, Germany aut NATIONALLICENCE 700 1- Röschke Joachim Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D-55101, Mainz, Germany aut NATIONALLICENCE 700 1- Müller Stefan Department of Urology, University of Mainz, D-55101, Mainz, Germany aut NATIONALLICENCE 700 1- Benkert Otto Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D-55101, Mainz, Germany aut NATIONALLICENCE 773 0- Archives of Sexual Behavior Kluwer Academic Publishers-Plenum Publishers 25/1(1996-02-01), 1-16 0004-0002 25:1<1 1996 25 10508 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer