caa a22 4500 477117910 CHVBK 20180405111627.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF02691480 doi (NATIONALLICENCE)springer-10.1007/BF02691480 Dissociation of oxytocin effects on body weight in two variants of female Sprague-Dawley rats [Elektronische Daten] [Kerstin Uvnas-Moberg, Pawel Alster, Maria Petersson] As a counterpoint to studies that make a case for the use of oxytocin in short-term inhibition of food intake, the aim of the present study was to determine whether the peptide facilitates weight gain in female rats in a more long-term perspective. Two different variants of female Sprague-Dawley rats were used. The two variants differed in daily weight gain (0.38 g/day vs. 1.41 g/day during 28 days), and were designated slowly and rapidly growing rats (SGR and RGR) respectively. Oxytocin 1 mg/kg given s.c. to SGR for a five-day period increased weight gain significantly in comparison to a previous five-day period with NaCl-treatment (18.0 g/5 days versus 5.0 g/5 days; p<0.01). In a separate study, oxytocin 1 mg/kg given for four days increased weight gain significantly in SGR versus saline-treated controls (7.5 g/4 days versus 1.6 g/4 days; p<0.05). The weight-difference persisted six days later (p<0.001). The weight increase of oxytocin occurred only during estrus (p<0.05) and was not accompanied by any measurable increase in food intake. In RGR, oxytocin-treatment decreased food intake significantly (p<0.001) and tended to decrease weight gain, although not significantly. The SGR and RGR also had different endocrine profiles with, for example, twice as high oxytocin (p<0.01) and insulin levels (p<0.01) in RGR compared to the SGR. These data suggest that oxytocin influences weight gain and food intake differently in the two variants of Sprague-Dawley rats, perhaps depending on factors such as endocrine profile and oxytocin sensitivity. Transaction Publishers, 1996 oxytocin nationallicence weight gain nationallicence food intake nationallicence estrous cycle nationallicence hormone levels nationallicence Uvnas-Moberg Kerstin Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institute, S-171 77, Stockholm, Sweden aut Alster Pawel Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institute, S-171 77, Stockholm, Sweden aut Petersson Maria Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institute, S-171 77, Stockholm, Sweden aut Integrative Physiological and Behavioral Science Springer-Verlag 31/1(1996-01-01), 44-55 1053-881X 31:1<44 1996 31 12124 https://doi.org/10.1007/BF02691480 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02691480 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Uvnas-Moberg Kerstin Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institute, S-171 77, Stockholm, Sweden aut NATIONALLICENCE 700 1- Alster Pawel Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institute, S-171 77, Stockholm, Sweden aut NATIONALLICENCE 700 1- Petersson Maria Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institute, S-171 77, Stockholm, Sweden aut NATIONALLICENCE 773 0- Integrative Physiological and Behavioral Science Springer-Verlag 31/1(1996-01-01), 44-55 1053-881X 31:1<44 1996 31 12124 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer