caa a22 4500 477118208 CHVBK 20180405111628.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF02699783 doi (NATIONALLICENCE)springer-10.1007/BF02699783 Effect of stress on the behavior and 5-HT system in Sprague-Dawley and Wistar Kyoto rat strains [Elektronische Daten] [William Paré, Shanaz Tejani-Butt] The effects of chronic novel stressors, for 21 days, on the behavior and the serotoninergic (5-HT) system in Sprague-Dawley (SD) and Wistar Kyoto (WKY) rats were studied. Open-field and forced-swim tests revealed a significantly greater behavioral depression in the WKY strain. SD rats showed a decrease in3H-DPAT binding to 5-HT1A receptors in the hippocampus, whereas WKY rats revealed an increase in3H-DPAT binding in the hippocampus and hypothalamus. Stress did not appear to alter the binding of3H-DPAT to 5-HT1A sites in the dorsal raphe or median raphe in either strains. SD rats revealed a modest increase in 5-HT transporter (5-HTT) sites in the cortex; WKY rats revealed a decrease in 5-HTT sites in the cortex and the hippocampus. Stress caused an increase in3H-CNIMI binding to 5-HTT sites in the dorsal and median raphe nuclei in both strains. The results suggest that the greater susceptibility to behavioral depression in WKY rats may account for the differential effects on 5HT1A sites as well as 5-HTT sites in limbic regions and cell body area as compared to SD rats. Springer, 1996 Stress nationallicence depression nationallicence serotoninergic nationallicence limbic nationallicence Wistar Kyoto rats nationallicence open field nationallicence forced swim test nationallicence Paré William Pavlovian Research Laboratory, VA Medical Center, 21902, Perry Point, MD aut Tejani-Butt Shanaz Department of Psychiatry, Univ. of Pennsylvania, 19104, Philadelphia, PA aut Integrative Physiological and Behavioral Science Springer-Verlag 31/2(1996-04-01), 112-121 1053-881X 31:2<112 1996 31 12124 https://doi.org/10.1007/BF02699783 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02699783 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Paré William Pavlovian Research Laboratory, VA Medical Center, 21902, Perry Point, MD aut NATIONALLICENCE 700 1- Tejani-Butt Shanaz Department of Psychiatry, Univ. of Pennsylvania, 19104, Philadelphia, PA aut NATIONALLICENCE 773 0- Integrative Physiological and Behavioral Science Springer-Verlag 31/2(1996-04-01), 112-121 1053-881X 31:2<112 1996 31 12124 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer