caa a22 4500 477118569 CHVBK 20180405111629.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00239313 doi (NATIONALLICENCE)springer-10.1007/BF00239313 Alteration of extracellular matrix in dilated cardiomyopathic hamster heart [Elektronische Daten] [Hitoshi Okada, Hideaki Kawaguchi, Toshiyuki Kudo, Hirofumi Sawa, Hiroshi Okamoto, Shouzi Watanabe, Kazushi Urasawa, Takeshi Murakami, Akira Kitabatake] The purpose of this study was to characterize the collagen in hereditary dilated cardiomyopathic hamster hearts, and to examine the participation of the collagen in the occurrence and progression of cardiomyopathy. BIO 53.58 hamsters (5, 10, 20 weeks old) were used as the model of dilated cardiomyopathy. Flb hamsters were used as controls. The collagen content was almost constant at any age in the Flb hamsters, but increased with age in BIO 53.58 hamsters. Type III collagen increased significantly in BIO 53.58 hamsters at 10 weeks. The acetic acid solubility of collagen decreased in BIO 53.58 hamsters as the fibrosis progressed, but was unchanged in controls. Reducible crosslinks showed a tendency to decrease progressively in BIO 53.58 hamsters. There were no differences between Flb and BIO 53.58 hamsters at 5 weeks, but its expression in BIO 53.58 hamsters at 10 and 20 weeks of age increased compared to Flb controls. These findings indicate that in the early phase of cardiomyopathy the extracellular matrix of the myocardium is rich in type III collagen. In the later phase, the matrix resembles that of hard tissues, whose collagen is mainly of type I collagen and is insoluble. These data suggest that the increased collagen synthesis may impair the cardiac function in the development of cardiomyopathy. Kluwer Academic Publishers, 1996 collagen nationallicence extracellular matrix nationallicence reducible crosslink nationallicence cardiomyopathy nationallicence Okada Hitoshi Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut Kawaguchi Hideaki Laboratory Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut Kudo Toshiyuki Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut Sawa Hirofumi Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut Okamoto Hiroshi Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut Watanabe Shouzi Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut Urasawa Kazushi Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut Murakami Takeshi Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut Kitabatake Akira Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 156/1(1996-03-01), 9-15 0300-8177 156:1<9 1996 156 11010 https://doi.org/10.1007/BF00239313 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00239313 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Okada Hitoshi Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Kawaguchi Hideaki Laboratory Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Kudo Toshiyuki Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Sawa Hirofumi Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Okamoto Hiroshi Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Watanabe Shouzi Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Urasawa Kazushi Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Murakami Takeshi Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Kitabatake Akira Department of Cardiovascular Medicine, Hokkaido University School of Medicine, 060, Sapporo, Japan aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 156/1(1996-03-01), 9-15 0300-8177 156:1<9 1996 156 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer