caa a22 4500 477118593 CHVBK 20180405111629.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00239323 doi (NATIONALLICENCE)springer-10.1007/BF00239323 Release of ischemia in paced rat Langendorff hearts by supply of L-carnitine: Role of endogenous long-chain acylcarnitine [Elektronische Daten] [W. Hulsmann, A. Peschechera, F. Serafini, L. Ferrari] Rat Langendorff hearts perfused with media that do not contain erythrocytes or fluorocarbon as oxygen carriers are borderline aerobic during 5 Hz pacing. This follows from the release of catabolic products measured: lactate, urate and lysophosphatidylcholine (IysoPC). Addition of L-carnitine to the perfusion medium reduced the level of these compounds, while the release of long-chain acylcarnitine (LCAC) increased. Previously, we found (Biochem Biophys Acta 847:62-66,1985) that micromolar LCAC protects membranes during reperfusion after ischemia, Therefore, the observed inverse relation between LCAC and the other compounds measured suggests that LCAC is the basis of an acute relief of imminent ischemia by carnitine addition. LCAC may be released from various cell types, including vascular endothelium, as demonstrated. The cationic amphiphilic nature of LCAC is responsible for protection of membrane functions in imminent ischemia. (Mol Cell Biochem 156: 87-91, 1996) Kluwer Academic Publishers, 1996 ischemia nationallicence heart nationallicence endothelium nationallicence lactate nationallicence urate nationallicence Iysolecithin nationallicence carnitine nationallicence long-chain acylcarnitine (LCAC) nationallicence Hulsmann W. Thorax Center, Erasmus University, Rotterdam, The Netherlands aut Peschechera A. Department of Biochemistry, Sigma-Tau, Pomezia, Italy aut Serafini F. Department of Biochemistry, Sigma-Tau, Pomezia, Italy aut Ferrari L. Department of Biochemistry, Sigma-Tau, Pomezia, Italy aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 156/1(1996-03-01), 87-91 0300-8177 156:1<87 1996 156 11010 https://doi.org/10.1007/BF00239323 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00239323 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hulsmann W. Thorax Center, Erasmus University, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Peschechera A. Department of Biochemistry, Sigma-Tau, Pomezia, Italy aut NATIONALLICENCE 700 1- Serafini F. Department of Biochemistry, Sigma-Tau, Pomezia, Italy aut NATIONALLICENCE 700 1- Ferrari L. Department of Biochemistry, Sigma-Tau, Pomezia, Italy aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 156/1(1996-03-01), 87-91 0300-8177 156:1<87 1996 156 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer