caa a22 4500 47711864X CHVBK 20180405111629.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF00426331 doi (NATIONALLICENCE)springer-10.1007/BF00426331 Influence of selenium on glutathione and some associated enzymes in rats with mammary tumor induced by 7,12-Dimethylbenz(a)anthracene [Elektronische Daten] [Natesan Chidambaram, Anantharanganathan Baradarajan] A recent finding in epidemiological and laboratory studies suggests that the ratio of selenium to glutathione is lower in breast cancer subjects than its control counterparts. Selenium, an antioxidant and anticarcinogen, can modify the status of glutathione and some associated enzymes by blocking peroxidation of lipids in membranes of cancer subjects. Studies were conducted using female albino rats of Wistar strain bearing mammary tumor induced by 7,12-dimethylbenz(a) anthracene to assess the biological role of selenium on some antioxidant enzymes associated with the maintenance of glutathione status. For induction of mammary tumor, 25 mg DMBA in a 1 ml emulsion of sunflower oil and physiological saline was injected subcutaneously to each rat. One group in each of control and tumor bearing rats, were fed 5 mg sodium selenite/kg diet from the day of tumor induction for 24 weeks. Increase in the reduced glutathione concentration was preceded by significant increase in the oxidized glutathione as well as in the activities of γ-glutamylcysteine synthetase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, and glucose-6-phosphate dehydrogenase by selenium administration in rats bearing tumor. However, selenium administration to rats bearing tumor decreased the activity of γ-glutamyl transpeptidase. These observations clearly demonstrate the influence of dietary selenium supplementation in correcting abnormal changes in glutathione turnover and some associated enzymes in tumor induced rats. Kluwer Academic Publishers, 1996 mammary tumor nationallicence DMBA nationallicence selenium nationallicence glutathione nationallicence γ-glutamylcystein synthetase nationallicence γ-glutamyl transpeptidase nationallicence antioxidative enzymes nationallicence Chidambaram Natesan Centre for Biosciences and Biotechnology, Indian Institute of Technology, 600 036 TN, Madras, India aut Baradarajan Anantharanganathan Centre for Biosciences and Biotechnology, Indian Institute of Technology, 600 036 TN, Madras, India aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 156/2(1996-09-01), 101-107 0300-8177 156:2<101 1996 156 11010 https://doi.org/10.1007/BF00426331 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00426331 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chidambaram Natesan Centre for Biosciences and Biotechnology, Indian Institute of Technology, 600 036 TN, Madras, India aut NATIONALLICENCE 700 1- Baradarajan Anantharanganathan Centre for Biosciences and Biotechnology, Indian Institute of Technology, 600 036 TN, Madras, India aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 156/2(1996-09-01), 101-107 0300-8177 156:2<101 1996 156 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer