caa a22 4500 477118666 CHVBK 20180405111629.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF00426342 doi (NATIONALLICENCE)springer-10.1007/BF00426342 Muscle fibers, ubiquinone and exercise capacity in effort angina [Elektronische Daten] [Jan Karlsson, Sigurd Gunnes, Bjarne Semb] Seventeen male patients with ischaemic heart disease (IHD) and effort angina performed OBLA exercise stress tests (set to 2.0 mmol × 1−1). They had muscle biopsies from the vastus lateralis muscle the day before coronary by-pass grafting, and from the internal and external intercostal, diaphragm and gastrocnemius muscles during surgery. They had a low WOBLA (83 ± 6 W, mean ± 1 S.E.M), WOBLA corresponded to 79 ± 4% (% WOBLA) of WSL (symptom limited or ‘maximal' capacity = 111 ± 11 W). Peak blood lactate concentration averaged 2.9 mmol × 1−1. Muscle fibre composition disclosed a depressed percent slow twitch (ST or ‘red') muscle fibres in the vastus lateralis and intercostal muscles (%ST). The diaphragm and gastrocnemius muscles had normal %ST. Intercostal muscles had elevated values for the fast twitch muscle fibre (FT) subgroup FTa indicative of endurance adaptation. The vastus lateralis, gastrocnemius and diaphragm muscles had normal muscle ubiquinone (UQ) contents, whereas the intercostals were depleted. Plasma contents of the antioxidants UQ and α-tocopherol were low as compared to healthy man. Kluwer Academic Publishers, 1996 effort angina nationallicence antioxidant vitamins nationallicence ubiquinone nationallicence vitamin Q nationallicence muscle fiber types nationallicence muscle oxidative capacity nationallicence oxygen availability nationallicence exercise capacity nationallicence Karlsson Jan OBLA AB, Box 242, S-185 23, Vaxholm, Sweden aut Gunnes Sigurd Department of Thoracic Surgery, Karolinska Institute, Sweden aut Semb Bjarne Department of Thoracic Surgery, Karolinska Institute, Sweden aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 156/2(1996-09-01), 179-184 0300-8177 156:2<179 1996 156 11010 https://doi.org/10.1007/BF00426342 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00426342 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karlsson Jan OBLA AB, Box 242, S-185 23, Vaxholm, Sweden aut NATIONALLICENCE 700 1- Gunnes Sigurd Department of Thoracic Surgery, Karolinska Institute, Sweden aut NATIONALLICENCE 700 1- Semb Bjarne Department of Thoracic Surgery, Karolinska Institute, Sweden aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 156/2(1996-09-01), 179-184 0300-8177 156:2<179 1996 156 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer