caa a22 4500 477118682 CHVBK 20180405111629.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF00426341 doi (NATIONALLICENCE)springer-10.1007/BF00426341 Muscle ubiquinone in male effort angina patients [Elektronische Daten] [Jan Karlsson, Lijun Lin, Sigurd Gunnes, Christer Sylvén, Hans Åström] Seven (7) males with effort angina and listed for coronary by-pass surgery had muscle biopsies taken from their vastus lateralis muscle for determination of muscle fiber types (%ST), ubiquinone (vitamin Q, UQ), oxidative and fermentative enzyme activities. Graded cycle ergometer exercise to determine intensities corresponding to onset of blood lactate accumulation set to 2.0 nimol × 1−1 (WOSLA) and symptom limited exercise (‘maximal', WSL) were also undertaken. WOBLA was positively related to %ST (r = 0.92, p < 0.001). %ST was on the other hand inversely related to UQ (r =−0.82, p < 0.05), the heart specific LD subunit LD-H (r =−0.96, p < 0.001), the isozyme LD3 as the fraction of LD (%LD3) (r=−0.93, p < 0.01), and the CK isozyme CKMB as the fraction of CK (%CKMB) (r = −0.88, p < 0.05). It was suggested that muscle UQ depletion in the patients was related to molecular oxygen and free oxygen radical formation. The lack of antioxidants then caused a radical trauma specifically to the ST fiber and their mitochondria. This could be a cause and-effect explanation for the selective ST fiber downregulation in effort angina and heart failure in general. Kluwer Academic Publishers, 1996 effort angina nationallicence antioxidant vitamins nationallicence ubiquinone nationallicence vitamin Q nationallicence muscle fiber types nationallicence muscle oxidative capacity nationallicence oxygen availability nationallicence exercise capacity nationallicence muscle fiber trauma nationallicence Karlsson Jan OBLA AB, Box 242, S-185 23, Vaxholm, Sweden aut Lin Lijun Department of Clinical Physiology, Karolinska Institute, Sweden aut Gunnes Sigurd Department of Thoracic Surgery Karolinska Institute, Sweden aut Sylvén Christer Department of Cardiology, Huddinge University Hospital, Karolinska Institute, Sweden aut Åström Hans Department of Thoracic Clinical Physiology, Karolinska Institute, Sweden aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 156/2(1996-09-01), 173-178 0300-8177 156:2<173 1996 156 11010 https://doi.org/10.1007/BF00426341 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00426341 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karlsson Jan OBLA AB, Box 242, S-185 23, Vaxholm, Sweden aut NATIONALLICENCE 700 1- Lin Lijun Department of Clinical Physiology, Karolinska Institute, Sweden aut NATIONALLICENCE 700 1- Gunnes Sigurd Department of Thoracic Surgery Karolinska Institute, Sweden aut NATIONALLICENCE 700 1- Sylvén Christer Department of Cardiology, Huddinge University Hospital, Karolinska Institute, Sweden aut NATIONALLICENCE 700 1- Åström Hans Department of Thoracic Clinical Physiology, Karolinska Institute, Sweden aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 156/2(1996-09-01), 173-178 0300-8177 156:2<173 1996 156 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer