caa a22 4500 477118720 CHVBK 20180405111629.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF00426335 doi (NATIONALLICENCE)springer-10.1007/BF00426335 Oxyradical scavenging effects of dehydroascorbate [Elektronische Daten] [Palaniyandi Devamanoharan, Steven Morris, Shambhu Varma] Dehydroascorbate (DHA) has been shown to possess vitamin C like activities as well as to protect the lens against oxidative stress and cataract formation. The results presented here suggest that some of the beneficial effects of DHA can be attributed to its property of undergoing peroxidative decarboxylation and of $$O_2^{\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\cdot}$}}{ - } } $$ scavenging. Incubation of 1-14C-DHA with peroxide at physiological pH has been found to liberate 14CO2 in quantitative yields, with recovery of 79-94%. The recovery increases with the increase in the amount of DHA used. Its $$O_2^{\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\cdot}$}}{ - } } $$ scavenging activity was apparent by inhibition of $$O_2^{\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\cdot}$}}{ - } } $$ dependent reduction of ferricytochrome c and nitroblue tetrazolium. The authenticity of the latter mechanism was proved by inhibition of the $$O_2^{ \cdot - } $$ dependent reactions also by superoxide dismutase. Kluwer Academic Publishers, 1996 dehydroascorbate nationallicence superoxide nationallicence hydrogen peroxide nationallicence decarboxylation nationallicence Devamanoharan Palaniyandi Department of Ophthalmology, University of Maryland at Baltimore, 21201, Baltimore, MD, USA aut Morris Steven Department of Ophthalmology, University of Maryland at Baltimore, 21201, Baltimore, MD, USA aut Varma Shambhu Department of Ophthalmology, University of Maryland at Baltimore, 21201, Baltimore, MD, USA aut Molecular and Cellular Biochemistry Kluwer Academic Publishers 156/2(1996-09-01), 131-134 0300-8177 156:2<131 1996 156 11010 https://doi.org/10.1007/BF00426335 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00426335 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Devamanoharan Palaniyandi Department of Ophthalmology, University of Maryland at Baltimore, 21201, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Morris Steven Department of Ophthalmology, University of Maryland at Baltimore, 21201, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Varma Shambhu Department of Ophthalmology, University of Maryland at Baltimore, 21201, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers 156/2(1996-09-01), 131-134 0300-8177 156:2<131 1996 156 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer