caa a22 4500 477118739 CHVBK 20180405111629.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00250996 doi (NATIONALLICENCE)springer-10.1007/BF00250996 Dietary linolenic acid-mediated increase in vascular prostacyclin formation [Elektronische Daten] [Heinz Rupp, Marian Turcani, Tadanari Ohkubo, Bernhard Maisch, Christian Brilla] To define vascular effects of an enhanced dietary α-linolenic acid intake, 28 spontaneously hypertensive rats were fed a 3% sunflowerseed oil (44% linoleic acid) diet; in 3 groups (7 rats each), the diet was supplemented with 1, 2.5 or 5% linseed oil containing 62% α-linolenic acid. α-Linolenic acid was incorporated up to 12% in the aorta of the 5% linseed oil group. The eicosapentaenoic acid content was not significantly increased. The content of arachidonic acid and docosatetraenoic acid was moderately reduced in rats fed 5% linseed oil. The generation of 6-keto-PGF1α (degradation product of prostacyclin) assessed by HPLC/electrochemical detection was, however, markedly increased (p < 0.05) in rats fed 2.5 and 5% linseed oil. The minor prostanoids TXB2, PGE2 and PGF2α were not significantly altered. The high systolic and diastolic blood pressure of SHR monitored by radio telemetry was more effectively reduced (p < 0.05) in the light, i.e. sleep, cycle. An increased prostacyclin formation and lowered vascular arachidonic acid content associated with enhanced dietary α-linolenic acid intake would thus be expected to prove beneficial in the prevention of vascular disorders. Kluwer Academic Publishers, 1996 fatty acid nationallicence dietary treatment nationallicence prostanoids nationallicence linseed oil nationallicence radio telemetry nationallicence spontaneously hypertensive rat nationallicence Rupp Heinz Institute of Physiology II, University of Tübingen, Germany aut Turcani Marian Institute of Physiology II, University of Tübingen, Germany aut Ohkubo Tadanari Institute of Physiology II, University of Tübingen, Germany aut Maisch Bernhard Institute of Physiology II, University of Tübingen, Germany aut Brilla Christian Institute of Physiology II, University of Tübingen, Germany aut Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www/wkap.nl 162/1(1996-03-01), 59-64 0300-8177 162:1<59 1996 162 11010 https://doi.org/10.1007/BF00250996 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00250996 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rupp Heinz Institute of Physiology II, University of Tübingen, Germany aut NATIONALLICENCE 700 1- Turcani Marian Institute of Physiology II, University of Tübingen, Germany aut NATIONALLICENCE 700 1- Ohkubo Tadanari Institute of Physiology II, University of Tübingen, Germany aut NATIONALLICENCE 700 1- Maisch Bernhard Institute of Physiology II, University of Tübingen, Germany aut NATIONALLICENCE 700 1- Brilla Christian Institute of Physiology II, University of Tübingen, Germany aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Kluwer Academic Publishers; http://www/wkap.nl 162/1(1996-03-01), 59-64 0300-8177 162:1<59 1996 162 11010 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer